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The evolving role of natural products in drug discovery
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Abstract
Natural products and their derivatives have historically been invaluable as a source
of therapeutic agents. However, in the past decade, research into natural products
in the pharmaceutical industry has declined, owing to issues such as the lack of compatibility
of traditional natural-product extract libraries with high-throughput screening. However,
as discussed in this review, recent technological advances that help to address these
issues, coupled with unrealized expectations from current lead-generation strategies,
have led to a renewed interest in natural products in drug discovery.