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      Three Cases of Congenital Growth Hormone Deficiency with Micropenis and Hypospadias: What Does Growth Hormone Have to Do with It?

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          This paper reports 3 cases of congenital GH deficiency with male pseudohermaphroditism. All 3 showed a normal male karyotype, hypospadias of different degrees, and, for 2 of them, micropenis. No müllerian structure was individualized since pelvic ultrasound and genitography were normal. Patient 1 was born with multiple anomalies and patient 3 showed partial agenesia of the corpus callosum. Only 1 patient showed complete anterior pituitary deficiency. Gonadotropin defects were not investigated. We postulate that GH might play a role in early testosterone stimulation, and thus in male sexual differentiation.

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          Author and article information

          Horm Res Paediatr
          Hormone Research in Paediatrics
          S. Karger AG
          February 1999
          02 June 1999
          : 51
          : 2
          : 101-104
          Department of Pediatric Endocrinology and Diabetology, Robert Debré Hospital, Paris, France
          23324 Horm Res 1999;51:101–104
          © 1999 S. Karger AG, Basel

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          Tables: 2, References: 11, Pages: 4
          Case Report


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