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      PEG-modified gold nanorods with a stealth character for in vivo applications.

      Journal of Controlled Release

      Animals, Cell Survival, drug effects, Cetrimonium Compounds, toxicity, Gold, administration & dosage, pharmacokinetics, HeLa Cells, Humans, Male, Mice, Nanostructures, Polyethylene Glycols, Tissue Distribution

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          Abstract

          Gold nanorods prepared in hexadecyltrimethylammonium bromide (CTAB) solution are expected to provide novel materials for photothermal therapy and photo-controlled drug delivery systems. Since gold nanorods stabilized with CTAB show strong cytotoxicity, we developed a technique to modify these with polyethyleneglycol (PEG) for medical applications. PEG-modification was achieved by adding mPEG-SH in the CTAB solution, then, excess CTAB was removed by dialysis. PEG-modified gold nanoparticles showed a nearly neutral surface, and had little cytotoxicity in vitro. Following intravenous injection into mice, 54% of injected PEG-modified gold nanoparticles were found in blood at 0.5 h after intravenous injection, whereas most of gold was detected in the liver in the case of original gold nanorods stabilized with CTAB.

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          Journal
          16876898
          10.1016/j.jconrel.2006.06.017

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