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      The Phosphoinositide Signal Transduction Pathway in the Pathogenesis of Alzheimer's Disease.

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          Abstract

          During aging and in age-associated disorders, such as Alzheimer's Disease (AD), learning abilities decline. Probably, disturbances in signal transduction in brain cells underlie the cognitive decline. The phosphorylation/dephosphorylation imbalance occurring in degenerating neurons was recently related to abnormal activity of one or more signal transduction pathways. AD is known to be associated with altered neuronal Ca2+ homeostasis, as Ca2+ accumulates in affected neurons leading to functional impairment. It is becoming more and more evident the involvement of signal transduction pathways acting upon Ca2+ metabolism and phosphorylation regulation of proteins. A growing interest raised around the role of signal transduction systems in a number of human diseases including neurodegenerative diseases, with special regard to the systems related to the phosphoinositide (PI) pathway and AD. The PI signal transduction pathway plays a crucial role, being involved in a variety of cell functions, such as hormone secretion, neurotransmitter signal transduction, cell growth, membrane trafficking, ion channel activity, cytoskeleton regulation, cell cycle control, apoptosis, cell and tissue polarity, and contributes to regulate the Ca2+ levels in the nervous tissue.

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          Author and article information

          Journal
          Curr Alzheimer Res
          Current Alzheimer research
          Bentham Science Publishers Ltd.
          1875-5828
          1567-2050
          February 22 2018
          : 15
          : 4
          Affiliations
          [1 ] Sense Organs Department, Faculty of Medicine and Dentistry, Sapienza University of Rome, Rome, Italy.
          Article
          CAR-EPUB-85509
          10.2174/1567205014666170829100230
          28847278
          5dee4be2-d508-4b77-ae5f-d577f326e2f1
          Copyright© Bentham Science Publishers; For any queries, please email at epub@benthamscience.org.

          Alzheimer's disease,Phospholipase C,diagnosis,pathogenesis.,phosphoinositide signaling,prognosis

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