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      Optical density of bone repair after implantation of homogenous demineralized dentin matrix in diabetic rabbits

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          Abstract

          This research evaluated the bone repair process after implantation of homogenous demineralized dentin matrix (HDDM) in surgical defects in the parietal bone of rabbits with alloxan-induced diabetes, using a polytetrafluorethylene (PTFe) barrier for guided bone regeneration. Thirty-six rabbits were used and divided into four groups: control (C, n = 12), diabetic (D, n = 12, left parietal bone), diabetic with PTFe (D-PTFe, same 12 rabbits, right parietal bone), and diabetic with PTFe associated to HDDM (D-PTFe+HDDM, n = 12). Bone defects were created in the parietal bone of the rabbits and the experimental treatments were performed, where applicable. The rabbits were sacrificed after 15, 30, 60 and 90 days. The bone defects were examined radiographically and by optical density (ANOVA and Tukey test, p < .05). The radiographic findings showed that the D-PTFe+HDDM group presented greater radiopacity and better trabecular bone arrangement when compared to that of the C, D and D-PTFe groups. The statistical analysis showed significant differences in the optical density of the newly formed bone among the studied groups. It was possible to conclude that HDDM was biocompatible in diabetic rabbits.

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          Induction of dentine in amputated pulp of dogs by recombinant human bone morphogenetic proteins-2 and -4 with collagen matrix.

          M Nakashima (1994)
          Recombinant human bone morphogenetic protein (BMP)-2, BMP-4 and transforming growth factor (TGF)-beta 1 combined with collagen matrix as a carrier were examined for their effects on pulp regeneration and dentine formation. Seventy days after implantation of 2 micrograms of BMP-2, mineralized osteodentine-like tissue containing embedded osteodentinocytes was seen in the cavity. Unmineralized fibrous tissue and pulp-like loose connective tissue were also found in the same cavity. In teeth implanted with 660 ng of BMP-2 only unmineralized fibrous and pulp tissues were seen. In teeth with 220 ng of BMP-2 or collagen alone, pulp tissue was seen. It is therefore likely that the cavity fills with pulp tissue and that spindle-shaped cells elaborate extracellular matrix that mineralizes to be osteodentine in a dose-dependent manner. Similar osteodentine was seen in teeth implanted with 4 micrograms of BMP-4 and collagen. No distinct tubular dentine was formed, unlike an earlier experiment in which BMP-2 or -4 was implanted with enriched, inactivated dentine matrix. These findings suggest that both BMP-2 and -4 induce osteodentine formation if combined with collagen matrix; some other matrix component present in inactivated dentine matrix might be essential for further differentiation into odontoblasts. In teeth implanted with TGF-beta 1, the carrier collagen remained in the cavity and little pulp tissue proliferation was seen, suggesting a possible inhibitory effect of TGF-beta 1 in pulp regeneration. It is likely that the response to growth and differentiation factors is dependent on the state of differentiation of pulp cells.
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            Wound healing around endosseous implants in experimental diabetes.

            M Nevins, N Y Karimbux, H Weber … (1998)
            Wound healing has been shown to be altered in diabetes mellitus. The aim of this study was to identify the effects of streptozotocin-induced diabetes on osseointegration. Diabetes was induced in 40-day-old rats by intraperitoneal injection of 70 mg per kg streptozotocin. At 14 days postinjection, implants were placed in the femora of 10 diabetic and 10 age-matched normal rats. Animals were sacrificed at 28 and 56 days following implantation. Histometric results indicated that the quantity of bone formation was similar for diabetic and control animals (P > .05). However, less bone-implant contact was observed for diabetic compared to control animals at both 28 and 56 days (P < .0001). This study demonstrates that the process of osseointegration is affected by streptozotocin-induced diabetes.
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              The effect of insulin therapy on osseointegration in a diabetic rat model.

              H. Weber, A Norkin, N Karimbux … (1999)
              As patients become edentulous, dental implants have been one treatment alternative. Although studies indicate that dental implants inserted in healthy patients have been successful, their placement in the diabetic patient remains controversial. The purpose of this study utilizing histometric parameters compares the course of osseous healing around endosseous implants in normal non-diabetic and insulin controlled diabetic rats. Diabetes was induced by a single intraperitoneal injection of streptozotocin. Blood glucose was monitored by the glucose-oxidase method and controlled with daily insulin injections. Sterile custom fabricated commercially pure solid cylinder titanium implants, with a titanium plasma-sprayed surface were placed in the femora of each animal. The results indicate that insulin therapy was able to upregulate the formation of bone around implants inserted in the streptozotocin-induced diabetic rat model. However, histometric parameters utilized indicated that although the total quantity of bone formation was greater in the insulin controlled group, there was significantly less bone-to-implant contact in the insulin controlled diabetic group as compared to normal non-diabetic controls.
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                Author and article information

                Journal
                Journal ID (publisher-id): bor
                Title: Brazilian Oral Research
                Abbreviated Title: Braz. oral res.
                Publisher: Sociedade Brasileira de Pesquisa Odontológica - SBPqO (São Paulo, SP, Brazil )
                ISSN (Print): 1806-8324
                ISSN (Electronic): 1807-3107
                Publication date (Print and electronic): September 2008
                Volume: 22
                Issue: 3
                Pages: 275-280
                Affiliations
                [01] Piracicaba SP orgnameState University of Campinas orgdiv1Piracicaba Dental School orgdiv2Department of Oral Diagnosis Brazil
                [02] Cuiabá MT orgnameUniversity of Cuiabá Brazil
                [03] Porto Alegre RS orgnamePontifical Catholic University of Rio Grande do Sul orgdiv1School of Dentistry orgdiv2Stomatology Clinic Brazil
                [04] São José dos Campos SP orgnameSão Paulo State University orgdiv1School of Dentistry of São José dos Campos orgdiv2Bioscience Center for Special Health Care Needs Brazil
                Article
                Publisher ID: S1806-83242008000300015 Publisher ID: S1806-8324(08)02200315
                DOI: 10.1590/S1806-83242008000300015
                PubMed ID: 18949316
                SO-VID: 5deeb710-7f6a-468e-a22e-d1eb01a224a9
                License:

                This work is licensed under a Creative Commons Attribution 4.0 International License.

                History
                Date accepted : 23 May 2007
                Date received : 01 December 2006
                Page count
                Figures: 0, Tables: 0, Equations: 0, References: 13, Pages: 6
                Product

                SciELO Brazil

                Categories
                Subject: Radiology

                Keywords: Diabetes mellitus,Guided tissue regeneration,Dentin,Bone regeneration,Bone density
                Data availability:
                Keywords: Diabetes mellitus, Guided tissue regeneration, Dentin, Bone regeneration, Bone density

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