Targeting Breast Cancer Metastasis

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Abstract

Metastasis is the leading cause of breast cancer-associated deaths. Despite the significant improvement in current therapies in extending patient life, 30–40% of patients may eventually suffer from distant relapse and succumb to the disease. Consequently, a deeper understanding of the metastasis biology is key to developing better treatment strategies and achieving long-lasting therapeutic efficacies against breast cancer. This review covers recent breakthroughs in the discovery of various metastatic traits that contribute to the metastasis cascade of breast cancer, which may provide novel avenues for therapeutic targeting.

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Author and article information

Journal

Journal ID (nlm-ta): Breast Cancer (Auckl)

Journal ID (iso-abbrev): Breast Cancer (Auckl)

Journal ID (publisher-id): Breast Cancer: Basic and Clinical Research

Title: Breast Cancer : Basic and Clinical Research

Publisher: Libertas Academica

ISSN (Electronic): 1178-2234

Publication date Collection: 2015

Publication date (Electronic): 01 September 2015

Volume: 9

Issue: Suppl 1

Pages: 23-34

Affiliations

[1 ]Cancer Program, Broad Institute of MIT and Harvard, Cambridge, MA, USA.

[2 ]Institute for Medical Engineering & Science (IMES), Massachusetts Institute of Technology, Cambridge, MA, USA.

[3 ]Human Oncology and Pathogenesis Program, Memorial Sloan Kettering Cancer Center, New York, NY, USA.

Author notes

CORRESPONDENCE: xjin@ 123456broadinstitute.org

Article

Publisher ID: bcbcr-suppl.1-2015-023

DOI: 10.4137/BCBCR.S25460

PMC ID: 4559199

PubMed ID: 26380552

SO-VID: 5e21a93d-d374-4392-8673-3ffabe86c667

License:

This is an open-access article distributed under the terms of the Creative Commons CC-BY-NC 3.0 License.

History

Date received : 21 May 2015

Date revision received : 06 August 2015

Date accepted : 10 August 2015

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