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      Paromomycin for cryptosporidiosis in AIDS: a prospective, double-blind trial.

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          Abstract

          To test the effects of paromomycin, 10 patients with AIDS and cryptosporidiosis were randomized to paromomycin or placebo in a double-blind trial. After 14 days, patients were switched to the other treatment for 14 additional days. Measures included the number and character of each stool and weekly 24-h stool specimens for weight and oocyst excretion. During the paromomycin treatment phase, oocyst excretion decreased from 314 x 10(6) to 109 x 10(6)24 h (P < .02). Oocyst excretion increased for the 4 patients initially on placebo compared to a median decrease of 128 x 10(6)/24 h for the 6 initially treated with drug (P < .02). Stool frequency also decreased more in those treated with drug (3.6 fewer vs. 1.25 fewer/24 h, P < .05). Trends favored drug over placebo for stool weight, stool character, and Karnofsky score. Paromomycin treatment resulted in improvement in both clinical and parasitologic parameters in cryptosporidiosis in AIDS.

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          Author and article information

          Journal
          J. Infect. Dis.
          The Journal of infectious diseases
          0022-1899
          0022-1899
          Aug 1994
          : 170
          : 2
          Affiliations
          [1 ] Dept. of Medicine, Baylor College of Medicine, Houston, TX 77030.
          Article
          10.1093/infdis/170.2.419
          8035029
          5e25804d-aac0-4347-81cc-a57df5e315e4
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