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      Activities of Garlic Oil, Garlic Powder, and Their Diallyl Constituents against Helicobacter pylori

      1 , 2 , 1
      Applied and Environmental Microbiology
      American Society for Microbiology

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          ABSTRACT

          Chronic Helicobacter pylori disease is reduced with Allium vegetable intake. This study was designed to assess the in vivo anti- H. pylori potential of a variety of garlic substances. The garlic materials all showed substantial but widely differing anti- H. pylori effects against all strains and isolates tested. The MICs (range, 8 to 32 μg/ml) and minimum bactericidal concentrations (MBCs) (range, 16 to 32 μg/ml) of undiluted garlic oil (GO) were smaller than those of garlic powder (GP) (MIC range, 250 to 500 μg/ml; MBC range, 250 to 500 μg/ml) but greater than the MIC of allicin (4.0 μg/ml) (Table 2) present in GP. Allicin (MIC, 6 μg/ml; MBC, 6 μg/ml) was more potent than diallyl disulfide (MIC range, 100 to 200 μg/ml; MBC range, 100 to 200 μg/ml), its corresponding sulfide, but of a strength similar to that of diallyl tetrasulfide (MIC range, 3 to 6 μg/ml; MBC range, 3 to 6 μg/ml). Antimicrobial activity of the diallyl sulfides increased with the number of sulfur atoms. Time course viability studies and microscopy showed dose-dependent anti- H. pylori effects with undiluted GO, GP, allicin, and diallyl trisulfide after a lag phase of ca. 1 to 2 h. Substantial in vitro anti- H. pylori effects of pure GO and GP and their diallyl sulfur components exist, suggesting their potential for in vivo clinical use against H. pylori infections.

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          Regression of primary gastric lymphoma of mucosa-associated lymphoid tissue type after cure of Helicobacter pylori infection

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            Ranitidine Bismuth Citrate With Clarithromycin Given Twice Daily Effectively Eradicates Helicobacter pylori and Heals Duodenal Ulcers

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              Author and article information

              Journal
              Applied and Environmental Microbiology
              Appl Environ Microbiol
              American Society for Microbiology
              0099-2240
              1098-5336
              May 2000
              May 2000
              : 66
              : 5
              : 2269-2273
              Affiliations
              [1 ]<!--label omitted: 1-->School of Health Sciences, University of Wolverhampton, Wolverhampton WV1 1DJ,1 and
              [2 ]<!--label omitted: 2-->School of Applied Sciences, University of Wolverhampton, Wolverhampton WV1 1SB,2 United Kingdom
              Article
              10.1128/AEM.66.5.2269-2273.2000
              101489
              10788416
              5e371163-5c6f-4c4b-8204-845e636fbe06
              © 2000

              https://journals.asm.org/non-commercial-tdm-license

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