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      Cytokine Filtration and Adsorption during Pre- and Postdilution Hemofiltration in Four Different Membranes

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          In the present in vitro study we investigated filtration and adsorption of tumor necrosis factor-α (TNF-α), interleukin-6 (IL-6) and interleukin-8 (IL-8) during predilution and postdilution hemofiltration with polysulfone, polyacrylonitrile, polyamide and cellulose triacetate membranes. The median sieving coefficient (SC) for all membranes was 0.0 for TNF-α, below 0.15 for IL-6 and below 0.15 for IL-8 during postdilution hemofiltration. Differences in SC between filtration modes were less than 0.05. Maximal differences in SC between membranes were 0.11 for IL-6, 0.0 for TNF-α, and 0.11 for IL-8. The progressive decrease in cytokine concentrations was identical between the two filtration modes and most pronounced with the polyacrylonitrile membrane (reduction 77% for IL-6, 39% for TNF-α and 95% for IL-8 after 4 h of hemofiltration). The relative contribution of adsorption to the reduction in cytokines was 100% for TNF-α for all membranes, between 53 (cellulose triacetate) and 83% (polyacrylonitrile) for IL-6, and for IL-8 between 0 (polysulfone) and 100% (polyacrylonitrile). In conclusion, the reduction in TNF-α, IL-6 and IL-8 was most impressive with the polyacrylonitrile membrane after 4 h of hemofiltration and was largely due to adsorption. Adsorption of TNF-α, IL-6 and IL-8 was also seen with the other membranes. None of the membranes filtered TNF-α. Sieving of IL-6 and IL-8 was low for all membranes with only marginal differences between membranes or between filtration modes.

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          Author and article information

          Blood Purif
          Blood Purification
          S. Karger AG
          October 1998
          29 January 1999
          : 16
          : 5
          : 261-268
          Departments of a Intensive Care and b Nephrology, Academic Medical Center, Amsterdam, The Netherlands
          14343 Blood Purif 1998;16:261–268
          © 1998 S. Karger AG, Basel

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          Page count
          Figures: 2, Tables: 1, References: 16, Pages: 8
          Self URI (application/pdf): https://www.karger.com/Article/Pdf/14343
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