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      Effects of Spinal Cord Stimulation and Coronary Artery Bypass Grafting on Myocardial Ischemia and Heart Rate Variability: Further Results from the ESBY Study


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          In the present study, 24-hour ECG recordings were analyzed from the Electrical Stimulation versus Coronary Artery Bypass Surgery (ESBY) Study where spinal cord stimulation was compared to CABG (coronary artery bypass grafting) in selected patients with severe angina pectoris. During the monitoring period, the spinal cord stimulation was discontinued to evaluate possible long-term effects of this treatment. The number of ischemic episodes and the duration of ischemia decreased in the CABG group at the follow-up when compared to spinal cord stimulation (p < 0.05). In spite of this, the number of anginal attacks decreased (p < 0.0001) in both groups. The fact that the anginal symptoms decreased in the spinal cord stimulation group in spite of discontinued stimulation and lack of effects on ischemic ST changes could indicate a long-term primary analgesic effect of this treatment in addition to the well-documented acute anti-ischemic effect.

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          Foot salvage and improvement of microvascular blood flow as a result of epidural spinal cord electrical stimulation

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            Does Heart Rate Variability Change in Angina Pectoris Patients Treated with Spinal Cord Stimulation?

            To determine whether spinal cord stimulation has any effect on the autonomic nervous tone of the heart, heart rate variability was used as an indicator of autonomic nervous control of the heart. The components time domain and power spectral analyses of heart rate variability were measured in 21 patients with angina pectoris. Twenty-four-hour Holter recordings were obtained before and after 12 months with spinal cord stimulation. No significant attenuation of time domain or spectral components of heart rate variability analyses were found. Apparently, spinal cord stimulation does not influence the autonomic tone of the heart.

              Author and article information

              S. Karger AG
              November 2000
              22 November 2000
              : 94
              : 1
              : 12-18
              aMultidisciplinary Pain Centre, Department of Medicine, and bDepartment of Clinical Physiology, Sahlgren’s University Hospital/Östra, Gothenburg, Sweden
              7040 Cardiology 2000;94:12–18
              © 2000 S. Karger AG, Basel

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              Page count
              Figures: 4, Tables: 2, References: 37, Pages: 7
              General Cardiology


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