14
views
0
recommends
+1 Recommend
0 collections
    0
    shares
      • Record: found
      • Abstract: found
      • Article: not found

      The Drosophila retinoid X receptor homolog ultraspiracle functions in both female reproduction and eye morphogenesis.

      1 , ,
      Development (Cambridge, England)
      The Company of Biologists

      Read this article at

      ScienceOpenPublisherPubMed
      Bookmark
          There is no author summary for this article yet. Authors can add summaries to their articles on ScienceOpen to make them more accessible to a non-specialist audience.

          Abstract

          Ultraspiracle (usp) encodes the Drosophila cognate of RXR, the human retinoid X receptor. To examine how RXR subfamily members function in development, we have undertaken a phenotypic analysis of usp mutants. usp is required at multiple stages of development for functions that occur in a wide variety of tissues. usp is required in the eye-antennal imaginal disc for normal eye morphogenesis and in the somatic and germline tissues of adult females for fertilization, eggshell morphogenesis and embryonic development. An unusual sunken eye phenotype with marked ventral-dorsal polarity appears to be caused by a lack of usp function in the imaginal disc cells that reside between the eye and antennal anlage. The usp functions include cell autonomous and non-cell autonomous components, suggesting that usp controls the production of factors important for both cell-cell communication and cellular differentiation. These usp signalling pathways have mechanistic parallels to steroid and retinoid action in developing vertebrate tissues.

          Related collections

          Author and article information

          Journal
          Development
          Development (Cambridge, England)
          The Company of Biologists
          0950-1991
          0950-1991
          Jun 1992
          : 115
          : 2
          Affiliations
          [1 ] Howard Hughes Medical Institute, Gene Expression Lab, Salk Institute for Biological Studies, La Jolla, California 92186-5800.
          Article
          10.1242/dev.115.2.449
          1330482
          5e530b92-2e26-464b-adc3-cbd198f686fb
          History

          Comments

          Comment on this article