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      • Record: found
      • Abstract: found
      • Article: found

      Modification of the Rabbit Electroretinogram by Reserpine

      research-article
      Author(s):
      Publication date (Electronic):
      Journal: Ophthalmic Research
      Publisher: S. Karger AG
      Keywords: Electroretinogram, Reserpine, Rabbit, Dopamine, L-Dopa, Oscillatory components, Adrenergic neurons

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          Abstract

          A single I v. dose of reserpine, 2 mg/kg, results in a substantial depression of the b-wave of the rabbit electroretinogram evoked by intense stimuli. All but one of the oscillatory components on the b-wave are suppressed, an effect which can be reversed by administering L-dopa. The amplitude of the a-wave remains essentially unchanged after reserpine, but the c-wave is markedly enhanced. The amplitude of the low voltage b-wave elicited by weak stimuli is not appreciably altered by reserpine.

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          Author and article information

          Journal
          Journal ID (publisher-id): ORE
          Journal ID (nlm-ta): Ophthalmic Res
          Journal ID (doi): 10.1159/issn.0030-3747
          Title: Ophthalmic Research
          Publisher: S. Karger AG
          ISSN (Print): 0030-3747
          ISSN (Electronic): 1423-0259
          Publication date Subscription-year: 1972
          Publication date (Print): July 2004
          Publication date (Electronic): 09 December 2009
          Volume: 4
          Issue: 2
          Pages: 65-75
          Affiliations
          Department of Physiology and Pharmacology, Duke University Medical Center, Durham, N.C.
          Article
          Publisher ID: 265957 Other ID: Ophthalmic Res 1972–73;4:65–75
          DOI: 10.1159/000265957
          SO-VID: 5e61ef82-9c08-45d7-b38c-6924543a2f2d
          Copyright © © 1972 S. Karger AG, Basel
          License:

          Copyright: All rights reserved. No part of this publication may be translated into other languages, reproduced or utilized in any form or by any means, electronic or mechanical, including photocopying, recording, microcopying, or by any information storage and retrieval system, without permission in writing from the publisher. Drug Dosage: The authors and the publisher have exerted every effort to ensure that drug selection and dosage set forth in this text are in accord with current recommendations and practice at the time of publication. However, in view of ongoing research, changes in government regulations, and the constant flow of information relating to drug therapy and drug reactions, the reader is urged to check the package insert for each drug for any changes in indications and dosage and for added warnings and precautions. This is particularly important when the recommended agent is a new and/or infrequently employed drug. Disclaimer: The statements, opinions and data contained in this publication are solely those of the individual authors and contributors and not of the publishers and the editor(s). The appearance of advertisements or/and product references in the publication is not a warranty, endorsement, or approval of the products or services advertised or of their effectiveness, quality or safety. The publisher and the editor(s) disclaim responsibility for any injury to persons or property resulting from any ideas, methods, instructions or products referred to in the content or advertisements.

          History
          Date received : 14 December 1971
          Date accepted : 09 March 1972
          Page count
          Pages: 11
          Categories
          Subject: Paper

          ScienceOpen disciplines: Vision sciences,Ophthalmology & Optometry,Pathology
          Keywords: Adrenergic neurons,Dopamine,Oscillatory components,Rabbit,Reserpine,Electroretinogram,L-Dopa
          Data availability:
          ScienceOpen disciplines: Vision sciences, Ophthalmology & Optometry, Pathology
          Keywords: Adrenergic neurons, Dopamine, Oscillatory components, Rabbit, Reserpine, Electroretinogram, L-Dopa

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