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      Estrous Cycle Changes after Prenatal and Neonatal Injections of Melatonin in Normal and Androgen-Sterilized Female Rats

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          Abstract

          Melatonin and testosterone propionate (TP), either alone or in combination, were injected into groups of pregnant rats and into 2-, 6-, and 13-day-old female animals. Melatonin had an inhibitory effect on vaginal introitus and decreased the incidence of estrous smears, when injected during the early postnatal period. TP inhibited the canalization of the vagina in prenatally injected rats and caused precocious vaginal patency in animals injected on days 6 and 13. Female rats given TP alone showed persistent vaginal cornifîcation, while melatonin in combination with TP reduced the incidence of such persistent vaginal estrus and established irregular vaginal cycling.

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          Author and article information

          Journal
          NEN
          Neuroendocrinology
          10.1159/issn.0028-3835
          Neuroendocrinology
          S. Karger AG
          0028-3835
          1423-0194
          1970
          1970
          19 March 2008
          : 6
          : 1
          : 10-18
          Affiliations
          Departments of Anatomy, University of Texas Medical Branch, Galveston, Texas, 1 and Emory University, Atlanta, Georgia, 2 USA
          Article
          121898 Neuroendocrinology 1970;6:10–18
          10.1159/000121898
          5461552
          © 1970 S. Karger AG, Basel

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          Page count
          Pages: 9
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