7
views
0
recommends
+1 Recommend
1 collections
    0
    shares
      • Record: found
      • Abstract: found
      • Article: found
      Is Open Access

      Toxicidad ocular por antimaláricos Translated title: Ocular toxicity of antimalarial drugs

      brief-report

      Read this article at

      Bookmark
          There is no author summary for this article yet. Authors can add summaries to their articles on ScienceOpen to make them more accessible to a non-specialist audience.

          Abstract

          En este artículo exponemos la evolución de una paciente afectada de Lupus eritematoso sistémico con expresión mucocutánea, hematológica, articular y renal. Debido a la afectación mucocutánea la paciente recibió tratamiento con cloroquina e hidroxicloroquina, presentando toxicidad ocular severa secundaria a antimaláricos. En este trabajo tratamos de hacer una revisión sobre el uso de antimaláricos en reumatología teniendo en cuenta su utilidad, dosis, efectos secundarios y factores de riesgo tales como dosis acumulada, dosis diaria por peso ideal, duración del tratamiento y función renal, así como de las recomendaciones de revisión oftalmológica en los pacientes tratados.

          Translated abstract

          We relate the evolution of a patient with Systemic Lupus Erythematosus with mucocutaneous, hematological, joint and renal expression. The skin lesions were treated with Chloroquine and Hydroxichloroquine and severe ocular toxicity related with antimalarials agents was developed. We revised the antimalarials use in Rheumatology, their utility, doses, adverse events and risk factors as cumulate doses, ideal daily doses, renal function and ophtalmological reviews recomendations.

          Related collections

          Most cited references12

          • Record: found
          • Abstract: found
          • Article: not found

          Ocular safety of hydroxychloroquine.

          Analysis of all published cases and Food and Drug Administration reports of retinopathy induced by hydroxychloroquine did not show any evidence of permanent visual-field scotomas occurring when the daily dose did not exceed 6.5 mg/kg body weight for maintenance therapy. Small risk factors may appear at this dosage level only when the duration of treatment exceeds ten years and/or chronic renal insufficiency is present. Because macular diseases not related to this drug commonly occur in older patients, periodic ophthalmologic examinations and central-field testing are recommended. A modified Amsler grid macular screening test is described, and participation of the treating physician in the testing program is encouraged to provide the maximum medicolegal protection.
            Bookmark
            • Record: found
            • Abstract: found
            • Article: not found

            Incidence of hydroxychloroquine retinopathy in 1,207 patients in a large multicenter outpatient practice.

            To define the true risk of hydroxychloroquine (HCQ) retinal toxicity by studying the largest single group yet evaluated.
              Bookmark
              • Record: found
              • Abstract: found
              • Article: not found

              Ophthalmologic considerations in using antimalarials in the United States.

              R I Rynes (1996)
              Ophthalmologic considerations continue to be important in the use of antimalarials. In the United States, hydroxychloroquine is prescribed much more frequently than chloroquine. Despite the favorable safety record, potential retinal problems cause patients to often be afraid to take antimalarial medicine. Ophthalmologic visits are recommended every three months by the drug manufacturer, but most often are scheduled every six months by physicians. Ophthalmologic examination includes questioning about visual symptoms, visual acuity tests, careful fundoscopic evaluation and a visual field assessment. Amsler grid self evaluation is not yet wide-spread.
                Bookmark

                Author and article information

                Contributors
                Role: ND
                Role: ND
                Role: ND
                Role: ND
                Journal
                ami
                Anales de Medicina Interna
                An. Med. Interna (Madrid)
                Arán Ediciones, S. L. (, , Spain )
                0212-7199
                April 2002
                : 19
                : 4
                : 43-45
                Affiliations
                [03] orgnameComplejo Hospitalario Juan Canalejo orgdiv1Servicio de Codificación
                [01] orgnameComplejo Hospitalario Juan Canalejo orgdiv1Servicio de Reumatología
                [02] orgnameComplejo Hospitalario Juan Canalejo orgdiv1Medicina Familiar y Comunitaria
                [04] A Coruña orgnameComplejo Hospitalario Juan Canalejo orgdiv1Servicio de Oftalmología
                Article
                S0212-71992002000400008
                10.4321/s0212-71992002000400008
                5e6f8b92-6a77-4e84-b80c-d64f83296abf

                This work is licensed under a Creative Commons Attribution-NonCommercial 3.0 International License.

                History
                Page count
                Figures: 0, Tables: 0, Equations: 0, References: 10, Pages: 3
                Product

                SciELO Spain


                Hidroxicloroquina,Cloroquina,Dosis,Toxicidad ocular,Factores de riesgo,Revisión Oftalmológica,Hydroxychloroquine,Chloroquine,Doses,Ocular toxicity,Risks factors,Ophtalmological reviews

                Comments

                Comment on this article