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      Revisiting QRS Detection Methodologies for Portable, Wearable, Battery-Operated, and Wireless ECG Systems

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          Abstract

          Cardiovascular diseases are the number one cause of death worldwide. Currently, portable battery-operated systems such as mobile phones with wireless ECG sensors have the potential to be used in continuous cardiac function assessment that can be easily integrated into daily life. These portable point-of-care diagnostic systems can therefore help unveil and treat cardiovascular diseases. The basis for ECG analysis is a robust detection of the prominent QRS complex, as well as other ECG signal characteristics. However, it is not clear from the literature which ECG analysis algorithms are suited for an implementation on a mobile device. We investigate current QRS detection algorithms based on three assessment criteria: 1) robustness to noise, 2) parameter choice, and 3) numerical efficiency, in order to target a universal fast-robust detector. Furthermore, existing QRS detection algorithms may provide an acceptable solution only on small segments of ECG signals, within a certain amplitude range, or amid particular types of arrhythmia and/or noise. These issues are discussed in the context of a comparison with the most conventional algorithms, followed by future recommendations for developing reliable QRS detection schemes suitable for implementation on battery-operated mobile devices.

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          Most cited references 47

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          Applications of adaptive filtering to ECG analysis: noise cancellation and arrhythmia detection.

          Several adaptive filter structures are proposed for noise cancellation and arrhythmia detection. The adaptive filter essentially minimizes the mean-squared error between a primary input, which is the noisy ECG, and a reference input, which is either noise that is correlated in some way with the noise in the primary input or a signal that is correlated only with ECG in the primary input. Different filter structures are presented to eliminate the diverse forms of noise: baseline wander, 60 Hz power line interference, muscle noise, and motion artifact. An adaptive recurrent filter structure is proposed for acquiring the impulse response of the normal QRS complex. The primary input of the filter is the ECG signal to be analyzed, while the reference input is an impulse train coincident with the QRS complexes. This method is applied to several arrhythmia detection problems: detection of P-waves, premature ventricular complexes, and recognition of conduction block, atrial fibrillation, and paced rhythm.
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            Physiological parameter monitoring from optical recordings with a mobile phone.

            We show that a mobile phone can serve as an accurate monitor for several physiological variables, based on its ability to record and analyze the varying color signals of a fingertip placed in contact with its optical sensor. We confirm the accuracy of measurements of breathing rate, cardiac R-R intervals, and blood oxygen saturation, by comparisons to standard methods for making such measurements (respiration belts, ECGs, and pulse-oximeters, respectively). Measurement of respiratory rate uses a previously reported algorithm developed for use with a pulse-oximeter, based on amplitude and frequency modulation sequences within the light signal. We note that this technology can also be used with recently developed algorithms for detection of atrial fibrillation or blood loss. © 2011 IEEE
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              Analysis of first-derivative based QRS detection algorithms.

              Accurate QRS detection is an important first step for the analysis of heart rate variability. Algorithms based on the differentiated ECG are computationally efficient and hence ideal for real-time analysis of large datasets. Here, we analyze traditional first-derivative based squaring function (Hamilton-Tompkins) and Hilbert transform-based methods for QRS detection and their modifications with improved detection thresholds. On a standard ECG dataset, the Hamilton-Tompkins algorithm had the highest detection accuracy (99.68% sensitivity, 99.63% positive predictivity) but also the largest time error. The modified Hamilton-Tompkins algorithm as well as the Hilbert transform-based algorithms had comparable, though slightly lower, accuracy; yet these automated algorithms present an advantage for real-time applications by avoiding human intervention in threshold determination. The high accuracy of the Hilbert transform-based method compared to detection with the second derivative of the ECG is ascribable to its inherently uniform magnitude spectrum. For all algorithms, detection errors occurred mainly in beats with decreased signal slope, such as wide arrhythmic beats or attenuated beats. For best performance, a combination of the squaring function and Hilbert transform-based algorithms can be applied such that differences in detection will point to abnormalities in the signal that can be further analyzed.
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                Author and article information

                Contributors
                Role: Editor
                Journal
                PLoS One
                PLoS ONE
                plos
                plosone
                PLoS ONE
                Public Library of Science (San Francisco, USA )
                1932-6203
                2014
                7 January 2014
                : 9
                : 1
                Affiliations
                [1 ]Department of Computing Science, University of Alberta, Edmonton, Alberta, Canada
                [2 ]Pattern Recognition Lab, Friedrich-Alexander-University Erlangen-Nuremberg, Bavaria, Germany
                [3 ]Graduate School of Biomedical Engineering, University of New South Wales, Sydney, New South Wales, Australia
                [4 ]School of Electrical and Electronic Engineering, University of Adelaide, Adelaide, South Australia, Australia
                Northwestern University, United States of America
                Author notes

                Competing Interests: Derek Abbott serves as an editor for PLOS ONE. This does not alter the authors' adherence to all the PLOS ONE policies on sharing data and materials.

                Conceived and designed the experiments: ME. Performed the experiments: ME BE. Analyzed the data: ME BE DA. Contributed reagents/materials/analysis tools: ME BE SD DA. Wrote the paper: ME BE SD DA.

                Article
                PONE-D-13-32369
                10.1371/journal.pone.0084018
                3883654

                This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

                Page count
                Pages: 18
                Funding
                The authors have no support or funding to report.
                Categories
                Research Article
                Computer Science
                Algorithms
                Engineering
                Bioengineering
                Biological Systems Engineering
                Biomedical Engineering
                Medical Devices
                Electrical Engineering
                Computer Engineering
                Signal Processing
                Medicine
                Cardiovascular
                Arrhythmias
                Diagnostic Medicine
                Clinical Neurophysiology
                Electroencephalography
                Test Evaluation

                Uncategorized

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