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      Different cognitive profiles of Brazilian patients with relapsing-remitting and primary progressive multiple sclerosis Translated title: Diferentes perfis cognitivos de pacientes brasileiros com esclerose múltipla remitente-recorrente e progressiva primária

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          Abstract

          Cognitive impairment is a symptom of multiple sclerosis (MS). Different clinical forms of multiple sclerosis have different cognitive profiles, according to findings of previous studies which used extensive batteries of neuropsychological tests. OBJECTIVE: To investigate cognitive profiles of Brazilian patients with relapsing-remitting multiple sclerosis (RRMS) and primary progressive multiple sclerosis (PPMS) by using a brief battery of neuropsychological tests. METHOD: Sixty-six patients, within 18-65 of age and 3-18 years of education, were paired with healthy control subjects, regarding gender, age, and education level. RESULTS: On Symbol Digit Modalities Test and Hooper Visual Organization Test, cognition was affected in 50% in RRMS and 69% in PPMS. Fluency of "F" was impaired in 24% of RRMS and 81% of PPMS. Immediate recall was affected in 32% of RRMS and in 63% of PPMS; whereas late recall, in 46% of relapsing-remitting and in 69% of primary progressive. CONCLUSION: Cognitive profiles of relapsing-remitting and primary progressive patients are different

          Translated abstract

          O comprometimento cognitivo é um sintoma da esclerose múltipla (EM). Formas clínicas diferentes da EM apresentam diferentes perfis cognitivos, de acordo com resultados de estudos anteriores que usaram bateria extensa de testes neuropsicológicos. OBJETIVO: Investigar o perfil cognitivo de pacientes com esclerose múltipla remitente-recorrente (EMRR) e esclerose múltipla progressiva primária (EMPP) utilizando uma bateria neuropsicológica breve. MÉTODO: 66 pacientes com idade de 18 a 65 anos, escolaridade 3 a 18 anos, foram pareados a controles por sexo, idade e escolaridade; e avaliados. RESULTADO: No Symbol Digit Modalitie Test e Hooper Visual Organization Test 50% com EMRR e 69% com EMPP apresentaram desempenho comprometido. Na fluência da letra "F" o comprometimento foi de 24% daqueles com EMRR e 81% com EMPP. Na evocação imediata o comprometimento foi de 32% na EMRR e 63% na EMPP e, evocação tardia em 46% na remitente-recorrente e 69% com progressiva primária. CONCLUSÃO: Os perfis cognitivos dos pacientes com esclerose múltipla remitente-recorrente e progressiva primária são diferentes.

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          Neuropsychology of multiple sclerosis.

          P. Rao (1995)
          Neuropsychological investigations have demonstrated that cognitive disorders are common (45-65%) in patients with multiple sclerosis. This review summarizes our current understanding of the nature and etiology of these disorders. Specifically, neuropsychological deficits regularly occur on measures of recent memory, attention, information-processing speed, executive functions, and visuospatial perception. In contrast, general intelligence, language, and certain aspects of memory (short-term capacity and implicit) are preserved. The degree and pattern of cognitive dysfunction is highly correlated with the amount and location of white-matter disease within the cerebral hemispheres. Natural history studies indicate that changes in cognitive test performance are correlated with increasing lesion load on magnetic resonance imaging. The development of brief cognitive-testing instruments for clinical screening and measuring treatment effects in clinical trials is underway. A clear weakness in the literature is the dearth of studies evaluating potential treatments for cognitive disorders.
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            Esclerose múltipla: manifestações clínicas, aspectos epidemiológicos e critérios diagnósticos

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              Clinical Course of Progressive Multiple Sclerosis in Brazilian Patients

              Objective: To describe the clinical course and outcome of multiple sclerosis with progressive onset in Brazilian patients. A total of 238 medical records were reviewed, 26 cases (10.9%) fulfilled Thompson criteria (2000), and 5.80% classified as primary progressive and 5.04% relapsing progressive according to Lublin and Reingold. Study Population: 19 Caucasians and 7 non-Caucasians; male:female ratio 1.2:1, mean age at onset was 34 ± 7.9 years. Results: Non-Caucasian patients had earlier onset of disease. The most common manifestations at onset were pyramidal and cerebellar (89% and 34.6%). After 11.3 ± 6.35 years of disease more than 50% of the patients had involvement of most of their functional systems. No statistically significant differences were observed between the subgroups. Conclusion: The clinical course and outcome of progressive multiple sclerosis in Brazil, a tropical country with low prevalence, were very similar to those in the multiple sclerosis high prevalence areas.
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                Author and article information

                Contributors
                Role: ND
                Role: ND
                Role: ND
                Role: ND
                Role: ND
                Journal
                anp
                Arquivos de Neuro-Psiquiatria
                Arq. Neuro-Psiquiatr.
                Academia Brasileira de Neurologia - ABNEURO (São Paulo )
                1678-4227
                August 2011
                : 69
                : 4
                : 590-595
                Affiliations
                [1 ] Pontifícia Universidade Católica do Rio de Janeiro Brazil
                [2 ] Universidade Estácio de Sá Brazil
                [3 ] Universidade Federal do Estado do Rio de Janeiro Brazil
                Article
                S0004-282X2011000500004
                10.1590/S0004-282X2011000500004
                5eac3c4b-3670-4d78-b4ae-ccabc81604fc

                http://creativecommons.org/licenses/by/4.0/

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                SciELO Brazil

                Self URI (journal page): http://www.scielo.br/scielo.php?script=sci_serial&pid=0004-282X&lng=en
                Categories
                NEUROSCIENCES
                PSYCHIATRY

                Neurosciences,Clinical Psychology & Psychiatry
                perfil cognitivo,bateria breve,esclerose múltipla,multiple sclerosis,cognitive profile,brief battery

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