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      Role of US military research programs in the development of US Food and Drug Administration--approved antimalarial drugs.

      Clinical Infectious Diseases: An Official Publication of the Infectious Diseases Society of America
      Antimalarials, therapeutic use, Drug Approval, Humans, Malaria, drug therapy, prevention & control, Military Medicine, Military Personnel, Research, United States, United States Food and Drug Administration

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          Abstract

          US military physicians and researchers helped identify the optimum treatment dose of the naturally occurring compound quinine and collaborated with the pharmaceutical industry in the development and eventual US Food and Drug Administration approval of the synthetic antimalarial drugs chloroquine, primaquine, chloroquine-primaquine, sulfadoxine-pyrimethamine, mefloquine, doxycycline, halofantrine, and atovaquone-proguanil. Because malaria parasites develop drug resistance, the US military must continue to support the creation and testing of new drugs to prevent and treat malaria until an effective malaria vaccine is developed. New antimalarial drugs also benefit civilians residing in and traveling to malarious areas.

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