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      Designing hydrogels for controlled drug delivery

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      Nature Reviews Materials
      Springer Nature

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          Abstract

          Hydrogel delivery systems can leverage therapeutically beneficial outcomes of drug delivery and have found clinical use. Hydrogels can provide spatial and temporal control over the release of various therapeutic agents, including small-molecule drugs, macromolecular drugs and cells. Owing to their tunable physical properties, controllable degradability and capability to protect labile drugs from degradation, hydrogels serve as a platform in which various physiochemical interactions with the encapsulated drugs control their release. In this Review, we cover multiscale mechanisms underlying the design of hydrogel drug delivery systems, focusing on physical and chemical properties of the hydrogel network and the hydrogel-drug interactions across the network, mesh, and molecular (or atomistic) scales. We discuss how different mechanisms interact and can be integrated to exert fine control in time and space over the drug presentation. We also collect experimental release data from the literature, review clinical translation to date of these systems, and present quantitative comparisons between different systems to provide guidelines for the rational design of hydrogel delivery systems.

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          Most cited references186

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                Author and article information

                Journal
                Nature Reviews Materials
                Nat. Rev. Mater.
                Springer Nature
                2058-8437
                October 18 2016
                October 18 2016
                : 1
                : 12
                : 16071
                Article
                10.1038/natrevmats.2016.71
                5898614
                29657852
                5eb4b2f7-62d3-401b-8fdf-838c64def848
                © 2016
                History

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