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      Electrophysiological Actions of a New Antiarrhythmic Agent on Isolated Preparations of the Canine Purkinje Fiber and Ventricular Muscle

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          Abstract

          The electrophysiological actions of a new antiarrhythmic drug [Kö1173, or 1-methyl-2-(2,6-xylyloxy)ethylamine hydrochloride] with a chemical structure similar to that of lidocaine, were investigated with an isolated canine preparation consisting of the right bundle branch and its attached ventricular muscle. At concentrations of less than 5 µg/ml conductivity in the Purkinje fibers or in the ordinary ventricular muscle was hardly affected by this drug, but conduction across the Purkinje fiber-muscle junction (P-M junction) was markedly depressed and blockage of conduction was often observed. Action potential durations of the Purkinje fibers were consistently shortened and the effective refractory period of the Purkinje fibers was also decreased at concentrations of 5 µg/ml or less. Over a range of concentrations from 2 to 20 µg/ml, spontaneous activity and the slope of phase 4 depolarization in the Purkinje fibers were significantly decreased. These results suggest that the electrophysiological action of Kö1173 resembles that of lidocaine, but include suppressive effects on conduction across the P-M junction at the concentration of 5 µg/ml.

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          Author and article information

          Journal
          CRD
          Cardiology
          10.1159/issn.0008-6312
          Cardiology
          S. Karger AG
          0008-6312
          1421-9751
          1976
          1976
          29 October 2008
          : 61
          : 5-6
          : 329-340
          Affiliations
          Division of Circulation and Respiration, Research Institute of Environmental Medicine, Nagoya University, Nagoya
          Article
          169779 Cardiology 1976;61:329–340
          10.1159/000169779
          © 1976 S. Karger AG, Basel

          Copyright: All rights reserved. No part of this publication may be translated into other languages, reproduced or utilized in any form or by any means, electronic or mechanical, including photocopying, recording, microcopying, or by any information storage and retrieval system, without permission in writing from the publisher. Drug Dosage: The authors and the publisher have exerted every effort to ensure that drug selection and dosage set forth in this text are in accord with current recommendations and practice at the time of publication. However, in view of ongoing research, changes in government regulations, and the constant flow of information relating to drug therapy and drug reactions, the reader is urged to check the package insert for each drug for any changes in indications and dosage and for added warnings and precautions. This is particularly important when the recommended agent is a new and/or infrequently employed drug. Disclaimer: The statements, opinions and data contained in this publication are solely those of the individual authors and contributors and not of the publishers and the editor(s). The appearance of advertisements or/and product references in the publication is not a warranty, endorsement, or approval of the products or services advertised or of their effectiveness, quality or safety. The publisher and the editor(s) disclaim responsibility for any injury to persons or property resulting from any ideas, methods, instructions or products referred to in the content or advertisements.

          Page count
          Pages: 12
          Categories
          Original Paper

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