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      Methylation Regulates Alpha-Synuclein Expression and Is Decreased in Parkinson's Disease Patients' Brains

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          Abstract

          Alpha-synuclein ( SNCA) is a major risk gene for Parkinson's disease (PD), and increased SNCA gene dosage results in a parkinsonian syndrome in affected families. We found that methylation of human SNCA intron 1 decreased gene expression, while inhibition of DNA methylation activated SNCA expression. Methylation of SNCA intron 1 was reduced in DNA from sporadic PD patients' substantia nigra, putamen, and cortex, pointing toward a yet unappreciated epigenetic regulation of SNCA expression in PD.

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          Author and article information

          Journal
          J Neurosci
          J. Neurosci
          jneuro
          jneurosci
          J. Neurosci
          The Journal of Neuroscience
          Society for Neuroscience
          0270-6474
          1529-2401
          5 May 2010
          : 30
          : 18
          : 6355-6359
          Affiliations
          [1]Department of Neurology, Rheinische Friedrich-Wilhelms-Universität, Universitätsklinikum Bonn, D-53105 Bonn, Germany
          Author notes
          Correspondence should be addressed to Ullrich Wüllner, Department of Neurology, Universitätsklinikum Bonn, Sigmund-Freud-Strasse 25, D 53105 Bonn, Germany. wuellner@ 123456uni-bonn.de

          *A.J. and I.S. contributed equally to this work.

          Article
          PMC6632710 PMC6632710 6632710 3596535
          10.1523/JNEUROSCI.6119-09.2010
          6632710
          20445061
          5eccf792-46e6-4ac9-83a1-2b665f957692
          Copyright © 2010 the authors 0270-6474/10/306355-05$15.00/0
          History
          : 10 December 2009
          : 19 January 2010
          : 24 February 2010
          Categories
          Brief Communications

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