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      Dose-dependent headache response and dilatation of limb and extracranial arteries after three doses of 5-isosorbide-mononitrate

      , , , ,
      European Journal of Clinical Pharmacology
      Springer Nature

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          Quality of life on angina therapy: a randomised controlled trial of transdermal glyceryl trinitrate against placebo.

          In a randomised controlled trial in 427 men with chronic stable angina continuous use of 5 mg transdermal glyceryl trinitrate (GTN) showed no advantage over placebo in terms of efficacy (anginal attack rates and sublingual GTN consumption) or quality of life (as measured with the sickness impact profile and a health index of disability). Patients on the active drug reported headaches more frequently than patients on placebo, and a higher proportion of them withdrew from the trial because of headache. Quality-of-life measurements showed a significant adverse effect of active treatment, principally in the social interaction dimension of the sickness impact profile. A similar effect was observed in placebo patients when crossed to active treatment in a 4-week single-blind period. The results suggest no benefit in the relief of chest pain from 5 mg transdermal GTN when used continuously.
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            Determination of the luminal diameter of the radial artery in man by high frequency ultrasound: A methodological study

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              The Effect of Intra-arterial Papaverine on the Regional Cerebral Blood Flow in Patients with Stroke or Intracranial Tumor

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                Author and article information

                Journal
                European Journal of Clinical Pharmacology
                Eur J Clin Pharmacol
                Springer Nature
                0031-6970
                1432-1041
                January 1992
                January 1992
                : 42
                : 1
                : 31-35
                Article
                10.1007/BF00314916
                1541314
                5ed6b9ee-7c07-4cfc-8066-42adccb1d72c
                © 1992
                History

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