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      Protective Effects of Green Tea Extract against Hepatic Tissue Injury in Streptozotocin-Induced Diabetic Rats

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          Abstract

          Although diabetic hepatopathy is potentially less common, it may be appropriate for addition to the list of target organ conditions related to diabetes. This study was designed to evaluate the hepatoprotective properties of green tea extract (GTE) in STZ-induced diabetes in rats. Wistar rats were made diabetic through single injection of STZ (75 mg/kg i.p.). The rats were randomly divided into four groups of 10 animals each: Group 1, healthy control; Group 2, nondiabetics treated with GTE administered orally (1.5%, w/v); Group 3, diabetics; Group 4, diabetics treated with GTE (1.5%, w/v) for 8 weeks. Serum biomarkers were assessed to determine hepatic injury. Malondialdehyde (MDA) and reduced glutathione (GSH) contents were measured to assess free radical activity in the liver tissue. Hepatic antioxidant activities of glutathione peroxidase (GSH-Px), superoxide dismutase (SOD), and catalase (CAT) were also determined. The biochemical findings were matched with histopathological verifications. Liver MDA content and serum levels of ALT, AST, ALP, and bilirubin in Group 3 significantly increased compared to Group 1 ( P < 0.05) and significantly decreased in Group 4 compared to Group 3 ( P < 0.05). Serum albumin level and GSH, SOD, CAT, and GSH-Px contents of the liver in Group 3 were significantly decreased compared to Group 1 ( P < 0.05) and were significantly increased in Group 4 compared to Group 3 ( P < 0.05). Histopathologically, the changes were in the same direction with biochemical findings. This study proved the hepatoprotective activity of GTE in experimentally induced diabetic rats.

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          Selenium: biochemical role as a component of glutathione peroxidase.

          When hemolyzates from erythrocytes of selenium-deficient rats were incubated in vitro in the presence of ascorbate or H(2)O(2), added glutathione failed to protect the hemoglobin from oxidative damage. This occurred because the erythrocytes were practically devoid of glutathione-peroxidase activity. Extensively purified preparations of glutathione peroxidase contained a large part of the (75)Se of erythrocytes labeled in vivo. Many of the nutritional effects of selenium can be explained by its role in glutathione peroxidase.
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            Polyphenolic flavanols as scavengers of aqueous phase radicals and as chain-breaking antioxidants.

            The purpose of this investigation was to establish the relative antioxidant activities in vitro of the flavanolic polyphenols, the catechins, and catechin-gallate esters. The relative antioxidant potentials were measured against radicals generated in the aqueous phase and against propagating lipid peroxyl radicals. The results show that in the aqueous phase their order of effectiveness as radical scavengers is epicatechin gallate (ECG) > epigallocatechin gallate (EGCG) > epigallocatechin (EGC) > gallic acid (GA) > epicatechin congruent to catechin; against propagating lipid peroxyl radical species, epicatechin and catechin are as effective as ECG and EGCG, the least efficacious being EGC and GA. This is consistent with their relative abilities to protect against consumption of LDL alpha-tocopherol. The results are discussed in the context of the most relevant antioxidant constituents of green tea extracts.
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              Spectrum of liver disease in type 2 diabetes and management of patients with diabetes and liver disease.

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                Author and article information

                Journal
                Evid Based Complement Alternat Med
                Evid Based Complement Alternat Med
                ECAM
                Evidence-based Complementary and Alternative Medicine : eCAM
                Hindawi Publishing Corporation
                1741-427X
                1741-4288
                2012
                27 February 2012
                27 February 2012
                : 2012
                Affiliations
                1Department of Biological Science, Ahar Branch, Islamic Azad University, Ahar, Iran
                2Department of Pathobiology, Tabriz Branch, Islamic Azad University, Tabriz, Iran
                3Department of Clinical Science, Tabriz Branch, Islamic Azad University, Tabriz, Iran
                4Young Researchers Club, Tabriz Branch, Islamic Azad University, Tabriz, Iran
                Author notes
                *Ali Akbar Abolfathi: abolfathiak@ 123456yahoo.co.uk

                Academic Editor: Olumayokun A. Olajide

                Article
                10.1155/2012/740671
                3432555
                22956978
                Copyright © 2012 Ali Akbar Abolfathi et al.

                This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

                Categories
                Research Article

                Complementary & Alternative medicine

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