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      Immunomodulatory potential of a bioactive fraction from the leaves of Phyllostachys bambusoides (bamboo) in BALB/c mice

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          Abstract

          In order to evaluate the role of ethyl acetate fraction (PB-EtAC) obtained from the Phyllostachys bambusoides leaves in the modulation of immune responses, detailed studies were carried out using a panel of in vivo assays. Oral administration of PB-EtAC (50–200 mg/Kg) stimulated the IgM and IgG titre expressed in the form of haemagglutination antibody (HA) titre. Further, it elicited a dose related increase in the delayed type hypersensitivity reaction (DTH) after 24 and 48 h in BALB/c mice. Besides augmenting the humoral and cell mediated immune response, the concentration of cytokines (IFN-γ, IL-2, and IL-4) in serum with respect to T cell interactions also increased significantly. It also induced macrophage phagocytosis, and nitric oxide (NO) production which resulted in a high degree of protection against Candida albicans and carbon clearance. Moreover, the enhancement in CD4 and CD8 cell populations as revealed by flow cytometry. Taken together this in vivo and ex vivo preclinical data, our results suggested that PB-EtAC acts as an effective immunostimulator eliciting both Th1 and Th2 immune responses. We are reporting first time the immunostimulatory potential of P. bambusoides and it might be regarded as a biological response modifier.

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              The biology of cachectin/TNF--a primary mediator of the host response.

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                Author and article information

                Journal
                EXCLI J
                EXCLI J
                EXCLI J
                EXCLI Journal
                Leibniz Research Centre for Working Environment and Human Factors
                1611-2156
                17 February 2014
                2014
                : 13
                : 137-150
                Affiliations
                [1 ]Department of Pharmacology, School of Pharmaceutical Sciences Shoolini University Solan (H.P.) 173229, India
                [2 ]Division of Pharmacology, Indian Institute of Integrative Medicine (CSIR), Jammu 180001, India
                [3 ]Department of Pharmacognosy, School of Pharmaceutical Sciences Shoolini University Solan (H.P.) 173229, India
                [4 ]Department of Pharmaceutical Chemistry, School of Pharmaceutical Sciences Shoolini University Solan (H.P.) 173229, India
                Author notes
                *To whom correspondence should be addressed: Sunil Kumar, Department of Pharmacology, School of Pharmaceutical Sciences Shoolini University Solan (H.P.) 173229, India, Mob.: +919736488612, E-mail: suny1435@ 123456gmail.com
                Article
                2013-599 Doc137
                4464317
                Copyright © 2014 Kumar et al.

                This is an Open Access article distributed under the following Assignment of Rights http://www.excli.de/documents/assignment_of_rights.pdf. You are free to copy, distribute and transmit the work, provided the original author and source are credited.

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