Eugeni Entchev:
ORCID: http://orcid.org/0000-0003-0744-5929
Role: ConceptualizationRole: InvestigationRole: MethodologyRole: SupervisionRole:
Writing – original draftRole: Writing – review & editing
Ingrid Jantzen:
ORCID: http://orcid.org/0000-0001-6057-0724
Role: InvestigationRole: Methodology
Philippe Masson: Role: ConceptualizationRole: InvestigationRole: MethodologyRole: Supervision
Stephanie Bocart: Role: InvestigationRole: Methodology
Bruno Bournique: Role: InvestigationRole: Methodology
Jean-Michel Luccarini: Role: MethodologyRole: Project administrationRole: Supervision
Andre Bouchot: Role: InvestigationRole: Methodology
Olivier Lacombe: Role: MethodologyRole: Supervision
Jean-Louis Junien: Role: ConceptualizationRole: SupervisionRole: Writing – review & editing
Pierre Broqua: Role: ConceptualizationRole: SupervisionRole: Writing – review & editing
Mireille Tallandier: Role: ConceptualizationRole: Project administrationRole: SupervisionRole: Writing
– review & editing
Sylvie Fournel-Gigleux: Role: Editor
Journal ID (nlm-ta): PLoS One
Journal ID (iso-abbrev): PLoS ONE
Journal ID (publisher-id): plos
Journal ID (pmc): plosone
Title:
PLoS ONE
Publisher:
Public Library of Science
(San Francisco, CA USA
)
ISSN
(Electronic):
1932-6203
Publication date
(Electronic):
15
May
2020
Publication date Collection: 2020
Volume: 15
Issue: 5
Electronic Location Identifier: e0233032
Affiliations
[1
]
Inventiva Pharma, Bourgogne-Franche-Comté, Daix, France
[2
]
DImaCell Core Facility, Inserm UMR1231 CellImaP site, Université de Bourgogne, Bourgogne-Franche-Comté,
Dijon, France
Author notes
Competing Interests: I have read the journal’s policy and the authors of this manuscript have financial
competing interests: PB is a co-founder and CSO of Inventiva; EE, IJ, OL, and MT are
employees of Inventiva; JLJ is the Chairman of the Scientific Advisory Board and consultant
for Inventiva and receives financial compensation from Inventiva; PM, SB, BB and JML
were employees of Inventiva while the study was conducted; PM and JLJ are co-inventors
on a patent for the use of odiparcil in the treatment of Mucopolysaccharidosis (FR1359657A);
Inventiva affiliated authors (EE, IJ, PM, SB, BB, JML, OL, JLJ, PB and MT) have received
stocks and shares from Inventiva; Odiparcil is being developed as a product for treatment
of Mucopolysaccharidosis by Inventiva. AB is an employee of a company (DimaCell) that
provided services on behalf of Inventiva. The authors confirm that “These do not alter
our adherence to PLOS ONE policies on sharing data and materials”.
Author information
Article
Publisher ID:
PONE-D-19-30400
DOI: 10.1371/journal.pone.0233032
PMC ID: 7228089
PubMed ID: 32413051
SO-VID: 5f2541d9-eee6-4726-9a2c-2c943daf471d
Copyright © © 2020 Entchev et al
License:
This is an open access article distributed under the terms of the
Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided
the original author and source are credited.
This study is funded by Inventiva SA ("Inventiva"). Inventiva provided support in
the form of salaries and other remuneration for authors (EE, IJ, PM, SB, BB, JML,
OL, JLJ, PB and MT; see declared competing interests), but did not have any additional
role in the study design, data collection and analysis, decision to publish, or preparation
of the manuscript. The specific roles of these authors are articulated in the ‘author
contributions’ section.
Subject:
Research Article
Subject:
Biology and Life Sciences
Subject:
Cell Biology
Subject:
Cellular Types
Subject:
Animal Cells
Subject:
Connective Tissue Cells
Subject:
Fibroblasts
Subject:
Biology and Life Sciences
Subject:
Anatomy
Subject:
Biological Tissue
Subject:
Connective Tissue
Subject:
Connective Tissue Cells
Subject:
Fibroblasts
Subject:
Medicine and Health Sciences
Subject:
Anatomy
Subject:
Biological Tissue
Subject:
Connective Tissue
Subject:
Connective Tissue Cells
Subject:
Fibroblasts
Subject:
Biology and Life Sciences
Subject:
Anatomy
Subject:
Renal System
Subject:
Kidneys
Subject:
Medicine and Health Sciences
Subject:
Anatomy
Subject:
Renal System
Subject:
Kidneys
Subject:
Biology and Life Sciences
Subject:
Anatomy
Subject:
Biological Tissue
Subject:
Connective Tissue
Subject:
Cartilage
Subject:
Medicine and Health Sciences
Subject:
Anatomy
Subject:
Biological Tissue
Subject:
Connective Tissue
Subject:
Cartilage
Subject:
Research and Analysis Methods
Subject:
Biological Cultures
Subject:
Cell Cultures
Subject:
Biology and Life Sciences
Subject:
Cell Biology
Subject:
Cellular Types
Subject:
Animal Cells
Subject:
Blood Cells
Subject:
White Blood Cells
Subject:
Biology and Life Sciences
Subject:
Cell Biology
Subject:
Cellular Types
Subject:
Animal Cells
Subject:
Immune Cells
Subject:
White Blood Cells
Subject:
Biology and Life Sciences
Subject:
Immunology
Subject:
Immune Cells
Subject:
White Blood Cells
Subject:
Medicine and Health Sciences
Subject:
Immunology
Subject:
Immune Cells
Subject:
White Blood Cells
Subject:
Research and Analysis Methods
Subject:
Animal Studies
Subject:
Experimental Organism Systems
Subject:
Model Organisms
Subject:
Mouse Models
Subject:
Research and Analysis Methods
Subject:
Model Organisms
Subject:
Mouse Models
Subject:
Research and Analysis Methods
Subject:
Animal Studies
Subject:
Experimental Organism Systems
Subject:
Animal Models
Subject:
Mouse Models
Subject:
Biology and Life Sciences
Subject:
Cell Biology
Subject:
Cellular Structures and Organelles
Subject:
Lysosomes
Subject:
Biology and Life Sciences
Subject:
Anatomy
Subject:
Respiratory System
Subject:
Trachea
Subject:
Medicine and Health Sciences
Subject:
Anatomy
Subject:
Respiratory System
Subject:
Trachea