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      Significance of Leukocyte Infiltration in Membranous Nephropathy with Segmental Glomerulosclerosis

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          Abstract

          Aim: To clarify the role of leukocyte subsets in the development of glomerulosclerosis (GS) and interstitial lesions which may contribute to the prognosis of membranous nephropathy (MN), we investigated infiltrating cells in both glomeruli and interstitium in biopsy specimens. Methods: Forty-one cases of MN were divided into two groups: MN with segmental GS (MN+GS; n = 21) and MN without GS (MN–GS; n = 20). There was no significant difference between both groups regarding clinical data at the time of the renal biopsy. The cells were analyzed with a three-layer indirect immunoperoxidase method using monoclonal antibodies against leukocyte common antigen, T cells, B cells, and monocytes/macrophages (Mo/Mφ). Results: Renal function tended to deteriorate during the final follow-up period in group MN+GS, but not in group MN–GS. The number of glomerular and interstitial leukocytes in group MN+GS were significantly higher than those in group MN–GS. Leukocytes were mostly Mo/Mφ in the glomerulus, while T cells and Mo/Mφ were predominant in the interstitium. In group MN+GS, there was a significant correlation in number of Mφ (CD68+) between glomeruli and interstitium, but not in group MN–GS. Conclusion: The results suggest that Mo/Mφ may play an important role in the development of segmental GS and interstitial lesions in MN which may be responsible for the incurability and poor prognosis.

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          Analysis of leukocyte surface antigens on ethanol-fixed paraffin-embedded tissue material

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            Author and article information

            Journal
            NEF
            Nephron
            10.1159/issn.1660-8151
            Nephron
            S. Karger AG
            1660-8151
            2235-3186
            1998
            December 1998
            07 December 1998
            : 80
            : 4
            : 414-420
            Affiliations
            2nd Department of Internal Medicine, Tohoku University School of Medicine, Sendai, Japan
            Article
            45213 Nephron 1998;80:414–420
            10.1159/000045213
            9832640
            © 1998 S. Karger AG, Basel

            Copyright: All rights reserved. No part of this publication may be translated into other languages, reproduced or utilized in any form or by any means, electronic or mechanical, including photocopying, recording, microcopying, or by any information storage and retrieval system, without permission in writing from the publisher. Drug Dosage: The authors and the publisher have exerted every effort to ensure that drug selection and dosage set forth in this text are in accord with current recommendations and practice at the time of publication. However, in view of ongoing research, changes in government regulations, and the constant flow of information relating to drug therapy and drug reactions, the reader is urged to check the package insert for each drug for any changes in indications and dosage and for added warnings and precautions. This is particularly important when the recommended agent is a new and/or infrequently employed drug. Disclaimer: The statements, opinions and data contained in this publication are solely those of the individual authors and contributors and not of the publishers and the editor(s). The appearance of advertisements or/and product references in the publication is not a warranty, endorsement, or approval of the products or services advertised or of their effectiveness, quality or safety. The publisher and the editor(s) disclaim responsibility for any injury to persons or property resulting from any ideas, methods, instructions or products referred to in the content or advertisements.

            Page count
            Figures: 2, Tables: 4, References: 32, Pages: 7
            Product
            Self URI (application/pdf): https://www.karger.com/Article/Pdf/45213
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            Original Paper

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