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      3D Bioprinting for Engineering Complex Tissues

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          Abstract

          Bioprinting is a 3D fabrication technology used to precisely dispense cell-laden biomaterials for the construction of complex 3D functional living tissues or artificial organs. While still in its early stages, bioprinting strategies have demonstrated their potential use in regenerative medicine to generate a variety of transplantable tissues, including skin, cartilage, and bone. However, current bioprinting approaches still have technical challenges in terms of high-resolution cell deposition, controlled cell distributions, vascularization, and innervation within complex 3D tissues. While no one-size-fits-all approach to bioprinting has emerged, it remains an on-demand, versatile fabrication technique that may address the growing organ shortage as well as provide a high-throughput method for cell patterning at the micrometer scale for broad biomedical engineering applications. In this review, we introduce the basic principles, materials, integration strategies and applications of bioprinting. We also discuss the recent developments, current challenges and future prospects of 3D bioprinting for engineering complex tissues. Combined with recent advances in human pluripotent stem cell technologies, 3D-bioprinted tissue models could serve as an enabling platform for high-throughput predictive drug screening and more effective regenerative therapies.

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          Author and article information

          Journal
          8403708
          31674
          Biotechnol Adv
          Biotechnol. Adv.
          Biotechnology advances
          0734-9750
          1873-1899
          23 January 2016
          23 December 2015
          Jul-Aug 2016
          01 July 2017
          : 34
          : 4
          : 422-434
          Affiliations
          [1 ]Department of Bioengineering, University of Washington, Seattle, WA 98195, USA
          [2 ]School of Engineering, The University of British Columbia, Kelowna, BC, V1V 1V7, Canada
          Author notes
          [# ]Corresponding Authors: Prof. Deok-Ho Kim, deokho@ 123456uw.edu , Prof. Keekyoung Kim, keekyoung.kim@ 123456ubc.ca
          [*]

          These authors contributed equally to this work.

          Article
          PMC4879088 PMC4879088 4879088 nihpa748887
          10.1016/j.biotechadv.2015.12.011
          4879088
          26724184
          5f534de1-83ee-4ad9-b4f7-495854bcc18c
          History
          Categories
          Article

          Bioprinting,drug screening,regenerative medicine,hydrogel,3D printing,tissue engineering,bioink

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