34
views
0
recommends
+1 Recommend
0 collections
    0
    shares
      • Record: found
      • Abstract: not found
      • Article: not found

      Potential beneficial effects of butyrate in intestinal and extraintestinal diseases

      World Journal of Gastroenterology
      Baishideng Publishing Group Inc.

      Read this article at

      ScienceOpenPublisherPMC
      Bookmark
          There is no author summary for this article yet. Authors can add summaries to their articles on ScienceOpen to make them more accessible to a non-specialist audience.

          Abstract

          The multiple beneficial effects on human health of the short-chain fatty acid butyrate, synthesized from non-absorbed carbohydrate by colonic microbiota, are well documented. At the intestinal level, butyrate plays a regulatory role on the transepithelial fluid transport, ameliorates mucosal inflammation and oxidative status, reinforces the epithelial defense barrier, and modulates visceral sensitivity and intestinal motility. In addition, a growing number of studies have stressed the role of butyrate in the prevention and inhibition of colorectal cancer. At the extraintestinal level, butyrate exerts potentially useful effects on many conditions, including hemoglobinopathies, genetic metabolic diseases, hypercholesterolemia, insulin resistance, and ischemic stroke. The mechanisms of action of butyrate are different; many of these are related to its potent regulatory effects on gene expression. These data suggest a wide spectrum of positive effects exerted by butyrate, with a high potential for a therapeutic use in human medicine.

          Related collections

          Author and article information

          Journal
          applab
          World Journal of Gastroenterology
          WJG
          Baishideng Publishing Group Inc.
          1007-9327
          2011
          2011
          : 17
          : 12
          : 1519
          Article
          10.3748/wjg.v17.i12.1519
          3070119
          21472114
          5f58d0e4-0c2e-426e-bdd2-367a41ef3c91
          © 2011

          Comments

          Comment on this article