Effects of blood pressure lowering on outcome incidence in hypertension. 1. Overview, meta-analyses, and meta-regression analyses of randomized trials.
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Abstract
Antihypertensive treatment is based on randomized controlled trials (RCTs) started
since 1966. Meta-analyses comprehensive of all RCTs but limited to RCTs investigating
blood pressure (BP) lowering in hypertensive patients are lacking.
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aDepartment of Cardiology, Helena Venizelou Hospital, Athens, Greece bDepartment of
Cardiovascular, Neural and Metabolic Sciences, San Luca Hospital, Istituto Auxologico
Italiano IRCCS cDepartment of Health Sciences, University of Milan Bicocca dScientific
Direction, Istituto Auxologico Italiano IRCCS eCentro Interuniversitario di Fisiologia
Clinica e Ipertensione, University of Milan, Milan, Italy.