Functional Abnormalities in Experimental Pyelonephritis

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Abstract

(1) Concentrating ability was studied in rats with experimental pyelonephritis. Maximal urinary concentration was shown to be reduced as early as one week after introduction of infection and persisted unchanged up to 21 weeks with repetitive injections of bacteria. (2) Glomerular filtration rate was unaltered throughout the study period. PAH clearance fell in the repetitively injected animals. (3) Sodium content of the renal papilla remained normal but urea content fell in the one-week singly injected and 21-week repetitively injected animals. (4) Histological examination showed progressive dilatation of residual collecting ducts. (5) It is suggested that the concentrating defect in early experimental pyelonephritis is due to impaired permeability of the collecting ducts to urea and water.

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Journal ID (publisher-id): NEF

Journal ID (nlm-ta): Nephron

Journal ID (doi): 10.1159/issn.1660-8151

Title: Nephron

Publisher: S. Karger AG

ISSN (Print): 1660-8151

ISSN (Electronic): 2235-3186

Publication date Subscription-year: 1965

Publication date (Print): 1965

Publication date (Electronic): 25 November 2008

Volume: 2

Issue: 4

Pages: 193-206

Affiliations

Medical Service, Wadsworth Hospital, Veterans Administration Center and the Department of Medicine, UCLA Center for the Health Sciences, Los Angeles, Calif.

Article

Publisher ID: 179403 Other ID: Nephron 1965;2:193–206

DOI: 10.1159/000179403

PubMed ID: 4955434

SO-VID: 5f6f44a0-e32b-4859-a6ec-56a1770d92e7

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Functional Abnormalities in Experimental Pyelonephritis

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Karger: Nephrology

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