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      Effects of treatment of preweaning dairy calves with recombinant bovine somatotropin on immune responses and somatotropic axis.

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          Abstract

          Weaning may be associated with negative energy balance and body weight loss when calves are still immunologically immature, predisposing them to infectious diseases. The aim of the present experiment was to investigate the effects of treatment of preweaning dairy calves with recombinant bovine somatotropin (rbST) on the somatotropic axis, selected immune parameters, and hematology of calves around weaning. Thirty-six Holstein female calves were randomly assigned to receive 1.5 to 1.8 mg of rbST (Posilac, Elanco Animal Health, Greenfield, IN) per kilogram of body weight or to receive injections of saline (saline solution 0.9%, Valley Vet Supply, Marysville, KS) every 7 d from 21 to 63 d of life. Calves were fed milk replacer ad libitum from birth to 38 d of age (d -11), when progressive weaning started, and calves were weaned at 49 d of age (d 0). Calves were weighed at birth and weekly from 21 to 63 d of age, when wither height also was measured. Calves were vaccinated with 0.5 mg of ovalbumin on study d -28 and -7. Blood samples were collected on d -28, -25, -21, -11, 0, 3, 7, and 14. Polymorphonuclear leukocytes were isolated and challenged ex vivo with Escherichia coli to determine phagocytosis and oxidative burst capacity. Additionally, expression of cluster of differentiation (CD)62L and CD18 by granulocyte, lymphocyte, and CD14+ monocyte were determined. Blood samples were also used to determine hematological parameters and concentrations of growth hormone, insulin-like growth factor-1, insulin, glucose, fatty acids, β-hydroxybutyrate, haptoglobin, and anti-ovalbumin IgG. Calves treated with rbST had greater concentrations of growth hormone and insulin-like growth factor-1 from d -25 to 14 than control calves, whereas insulin, fatty acid, and β-hydroxybutyrate concentrations did not differ. On d -11, glucose concentration was greater for rbST-treated calves. Treatment did not affect polymorphonuclear lymphocyte phagocytosis and oxidative burst, but intensity of expression of CD62L and CD18 by granulocytes tended to be increased by rbST treatment. Treatment did not affect the concentration of anti-ovalbumin IgG in serum. Haptoglobin concentration was reduced in rbST treated calves on d 3 and we noted a tendency for hematocrit to be lower in rbST-treated calves. Treatment did not affect body weight, wither height, and average daily gain, despite the fact that rbST-treated calves had lower daily milk replacer intake. The relatively minor improvements in immune responses resulting from rbST treatment of weaning calves may not be sufficient to reduce the incidence of infectious diseases.

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          Author and article information

          Journal
          J Dairy Sci
          Journal of dairy science
          American Dairy Science Association
          1525-3198
          0022-0302
          Jul 2018
          : 101
          : 7
          Affiliations
          [1 ] Department of Animal Science, Escola de Veterinária da Universidade Federal de Minas Gerais, Belo Horizonte 567; Department of Large Animal Clinical Sciences, University of Florida, Gainesville 32608.
          [2 ] Department of Animal Science, Escola de Veterinária da Universidade Federal de Minas Gerais, Belo Horizonte 567.
          [3 ] Department of Large Animal Clinical Sciences, University of Florida, Gainesville 32608.
          [4 ] Department of Animal Sciences, University of Florida, Gainesville 32608.
          [5 ] Department of Animal Science, South Dakota State University, Brookings 57007.
          [6 ] Department of Animal and Food Sciences, Texas Tech University, Lubbock 79409.
          [7 ] Department of Large Animal Clinical Sciences, University of Florida, Gainesville 32608; Department of Animal Sciences, University of Florida, Gainesville 32608. Electronic address: rcchebel@ufl.edu.
          Article
          S0022-0302(18)30338-2
          10.3168/jds.2017-13917
          29655555
          5f784d32-f658-42fe-94a2-70bad2cd4ed2
          Copyright © 2018 American Dairy Science Association. Published by Elsevier Inc. All rights reserved.
          History

          dairy calves,immune parameters,somatotropin
          dairy calves, immune parameters, somatotropin

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