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      MicroRNAs: Synthesis, mechanism, function, and recent clinical trials

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      Biochimica et Biophysica Acta (BBA) - Molecular Cell Research

      Elsevier BV

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          Abstract

          MicroRNAs (miRNAs) are a class of small, endogenous RNAs of 21-25 nucleotides (nts) in length. They play an important regulatory role in animals and plants by targeting specific mRNAs for degradation or translation repression. Recent scientific advances have revealed the synthesis pathways and the regulatory mechanisms of miRNAs in animals and plants. miRNA-based regulation is implicated in disease etiology and has been studied for treatment. Furthermore, several preclinical and clinical trials have been initiated for miRNA-based therapeutics. In this review, the existing knowledge about miRNAs synthesis, mechanisms for regulation of the genome, and their widespread functions in animals and plants is summarized. The current status of preclinical and clinical trials regarding miRNA therapeutics is also reviewed. The recent findings in miRNA studies, summarized in this review, may add new dimensions to small RNA biology and miRNA therapeutics. Copyright © 2010 Elsevier B.V. All rights reserved.

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          Author and article information

          Journal
          Biochimica et Biophysica Acta (BBA) - Molecular Cell Research
          Biochimica et Biophysica Acta (BBA) - Molecular Cell Research
          Elsevier BV
          01674889
          November 2010
          November 2010
          : 1803
          : 11
          : 1231-1243
          Article
          10.1016/j.bbamcr.2010.06.013
          20619301
          © 2010

          https://www.elsevier.com/tdm/userlicense/1.0/

          https://www.elsevier.com/open-access/userlicense/1.0/

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