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      Evidence for the presence in Burkholderia pseudomallei of a type III secretion system-associated gene cluster.

      Journal of Medical Microbiology
      Amino Acid Sequence, Bacterial Proteins, chemistry, genetics, secretion, Blotting, Southern, Burkholderia pseudomallei, pathogenicity, Chromosome Mapping, Cloning, Molecular, Cosmids, DNA Primers, DNA, Bacterial, analysis, Electrophoresis, Agar Gel, Gene Library, Humans, Melioidosis, microbiology, Molecular Sequence Data, Multigene Family, Polymerase Chain Reaction, Sequence Alignment, Sequence Analysis, DNA, Sequence Homology, Amino Acid, Surface Properties, Virulence

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          Abstract

          Burkholderia pseudomallei, the causative agent of melioidosis, contains a cluster of putative genes homologous to those encoding HpaP, HrcQ, HrcR, HrcS and HrpV in the plant pathogen Ralstonia solanacearum. In R. solanacearum, these genes form part of a type III secretion-associated pathogenicity island. The order of the genes in B. pseudomallei is directly equivalent to that found in R. solanacearum. The B. pseudomallei proteins share 49.5% (HpaP), 52.6% (HrcQ), 80.0% (HrcR), 72.1% (HrcS) and 46.7% (HrpV) similarity, respectively, with their equivalent R. solanacearum proteins. The presence of type III secretion-associated genes in B. pseudomallei pathogens suggests a possible role for type III secretion systems in the pathogenicity of this organism.

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