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      Reduction in delta activity predicted improved negative affect in Major Depressive Disorder.

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          Abstract

          While prior research has demonstrated a paradoxical antidepressant effect of slow-wave disruption (SWD), the specific dimensions of depression affected is still unclear. The current study aimed to extend this research by utilizing a dimensional approach in examining the antidepressant effects of SWD. Of particular interest is the affective dimension, as negative affect in depression is arguably the most salient characteristic of depression. This sample included 16 individuals with depression (10 female) recruited from the community. Participants slept in the lab for three nights (adaptation, baseline night, and SWD) with polysomnography, and completed measures of negative affect and depression severity the following morning. Results show that reduction in delta power was linearly associated with improved negative affect. Comparison of individual change scores revealed that half of the individuals showed improved negative affect, which is comparable to the reported 40-60% antidepressant response rate to sleep deprivation. Results suggest that vulnerability in the sleep homeostatic system may be a contributing individual differences factor in response to slow-wave disruption in depression.

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          Author and article information

          Journal
          Psychiatry Res
          Psychiatry research
          Elsevier BV
          1872-7123
          0165-1781
          Aug 30 2015
          : 228
          : 3
          Affiliations
          [1 ] Department of Psychiatry University of Michigan, Ann Arbor, Ann Arbor MI 48105, United States. Electronic address: pcheng1@hfhs.org.
          [2 ] Department of Psychiatry University of Michigan, Ann Arbor, Ann Arbor MI 48105, United States.
          Article
          S0165-1781(15)00312-1
          10.1016/j.psychres.2015.05.037
          26123231
          5f9a7209-251b-4b6d-a800-07eb6b543bfa
          History

          Slow-wave sleep,Affect,Depression,Slow-wave disruption
          Slow-wave sleep, Affect, Depression, Slow-wave disruption

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