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      Effects of Dexamethasone Phosphate on the Formation of Ester Forms of Riboflavin in the Lens

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          Abstract

          We investigated the effects of excess administration of dexamethasone phosphate (Dx) on the synthesis of ester forms of riboflavin in the rat lens. The formation of ester forms of riboflavin in the lens was reduced by intraperitoneal administration of Dx. No effects on the synthesis were noted upon the administration of a single dose of Dx. Our results show that phosphorylation of riboflavin in the lens is reduced under the condition of excess administration of Dx.

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          Author and article information

          Journal
          ORE
          Ophthalmic Res
          10.1159/issn.0030-3747
          Ophthalmic Research
          S. Karger AG
          0030-3747
          1423-0259
          1986
          1986
          04 December 2009
          : 18
          : 5
          : 279-281
          Affiliations
          Department of Biochemistry, School of Medicine, Iwate Medical University, Morioka, Japan
          Article
          265448 Ophthalmic Res 1986;18:279–281
          10.1159/000265448
          3808593
          5fbe87a5-262b-4b28-96ea-d9c405ec39fd
          © 1986 S. Karger AG, Basel

          Copyright: All rights reserved. No part of this publication may be translated into other languages, reproduced or utilized in any form or by any means, electronic or mechanical, including photocopying, recording, microcopying, or by any information storage and retrieval system, without permission in writing from the publisher. Drug Dosage: The authors and the publisher have exerted every effort to ensure that drug selection and dosage set forth in this text are in accord with current recommendations and practice at the time of publication. However, in view of ongoing research, changes in government regulations, and the constant flow of information relating to drug therapy and drug reactions, the reader is urged to check the package insert for each drug for any changes in indications and dosage and for added warnings and precautions. This is particularly important when the recommended agent is a new and/or infrequently employed drug. Disclaimer: The statements, opinions and data contained in this publication are solely those of the individual authors and contributors and not of the publishers and the editor(s). The appearance of advertisements or/and product references in the publication is not a warranty, endorsement, or approval of the products or services advertised or of their effectiveness, quality or safety. The publisher and the editor(s) disclaim responsibility for any injury to persons or property resulting from any ideas, methods, instructions or products referred to in the content or advertisements.

          History
          Page count
          Pages: 3
          Categories
          Original Paper

          Vision sciences,Ophthalmology & Optometry,Pathology
          Steroid cataracts,Lens,Dexamethasone phosphate,Rat,Ester forms of riboflavin

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