11
views
0
recommends
+1 Recommend
0 collections
    0
    shares
      • Record: found
      • Abstract: found
      • Article: not found

      LINC00472 expression is regulated by promoter methylation and associated with disease-free survival in patients with grade 2 breast cancer

      research-article

      Read this article at

      ScienceOpenPublisherPMC
      Bookmark
          There is no author summary for this article yet. Authors can add summaries to their articles on ScienceOpen to make them more accessible to a non-specialist audience.

          Abstract

          Long non-coding RNAs (lncRNAs) are a class of newly recognized DNA transcripts that have diverse biological activities. Dysregulation of lncRNAs may be involved in many pathogenic processes including cancer. Recently, we found an intergenic lncRNA, LINC00472, whose expression was correlated with breast cancer progression and patient survival. Our findings were consistent across multiple clinical datasets and supported by results from in vitro experiments. To evaluate further the role of LINC00472 in breast cancer, we used various online databases to investigate possible mechanisms that might affect LINC00472 expression in breast cancer. We also analyzed associations of LINC00472 with estrogen receptor, tumor grade, and molecular subtypes in additional online datasets generated by microarray platforms different from the one we investigated previously. We found that LINC00472 expression in breast cancer was regulated more possibly by promoter methylation than by the alteration of gene copy number. Analysis of additional datasets confirmed our previous findings of high expression of LINC00472 associated with ER-positive and low-grade tumors and favorable molecular subtypes. Finally, in nine datasets, we examined the association of LINC00472 expression with disease-free survival in patients with grade 2 tumors. Meta-analysis of the datasets showed that LINC00472 expression in breast tumors predicted the recurrence of breast cancer in patients with grade 2 tumors. In summary, our analyses confirm that LINC00472 is functionally a tumor suppressor, and that assessing its expression in breast tumors may have clinical implications in breast cancer management.

          Related collections

          Author and article information

          Journal
          8111104
          1254
          Breast Cancer Res Treat
          Breast Cancer Res. Treat.
          Breast cancer research and treatment
          0167-6806
          1573-7217
          7 December 2015
          13 November 2015
          December 2015
          01 December 2016
          : 154
          : 3
          : 473-482
          Affiliations
          [1 ] Cancer Epidemiology Program, University of Hawaii Cancer Center, 701 Ilalo Street, Honolulu, HI 96813, USA
          [2 ] Cancer Biology Program, University of Hawaii Cancer Center, Honolulu, HI, USA
          [3 ] Department of Chronic Disease Epidemiology, Yale School of Public Health, New Haven, CT, USA
          [4 ] Department of Surgical Sciences, University of Turin, Turin, Italy
          Author notes
          Article
          PMC4854534 PMC4854534 4854534 nihpa738328
          10.1007/s10549-015-3632-8
          4854534
          26564482
          5fc5c467-9e7a-481e-94e3-9e414568898b
          History
          Categories
          Article

          Grade 2 tumor,Methylation,Prognosis,Breast, LINC00472 ,Long non-coding RNA

          Comments

          Comment on this article