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      Glucagonlike Peptide 2 Analogue Teduglutide : Stimulation of Proliferation but Reduction of Differentiation in Human Caco-2 Intestinal Epithelial Cells

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      JAMA Surgery
      American Medical Association (AMA)

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          Abstract

          Short bowel syndrome occurs when a shortened intestine cannot absorb sufficient nutrients or fluids. Teduglutide is a recombinant analogue of human glucagonlike peptide 2 that reduces dependence on parenteral nutrition in patients with short bowel syndrome by promoting enterocytic proliferation, increasing the absorptive surface area. However, enterocyte function depends not only on the number of cells that are present but also on differentiated features that facilitate nutrient absorption and digestion.

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          Author and article information

          Journal
          JAMA Surgery
          JAMA Surg
          American Medical Association (AMA)
          2168-6254
          November 01 2013
          November 01 2013
          : 148
          : 11
          : 1037
          Article
          10.1001/jamasurg.2013.3731
          4574866
          24068167
          5fda7fd0-e1e1-46af-957e-17da9e4eec1a
          © 2013
          History

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