Glucagonlike Peptide 2 Analogue Teduglutide : Stimulation of Proliferation but Reduction of Differentiation in Human Caco-2 Intestinal Epithelial Cells
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Abstract
Short bowel syndrome occurs when a shortened intestine cannot absorb sufficient nutrients
or fluids. Teduglutide is a recombinant analogue of human glucagonlike peptide 2 that
reduces dependence on parenteral nutrition in patients with short bowel syndrome by
promoting enterocytic proliferation, increasing the absorptive surface area. However,
enterocyte function depends not only on the number of cells that are present but also
on differentiated features that facilitate nutrient absorption and digestion.