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      Controlled, blinded force platform analysis of the effect of intraarticular injection of autologous adipose-derived mesenchymal stem cells associated to PRGF-Endoret in osteoarthritic dogs

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          Abstract

          Background

          Adipose-derived mesenchymal stem cell (ADMSC) therapy in regenerative medicine is a rapidly growing area of research and is currently also being used to treat osteoarthritis (OA). Force platform analysis has been consistently used to verify the efficacy of different therapeutic strategies for the treatment of OA in dogs, but never with AD-MSC.

          The aim of this study was to use a force platform to measure the efficacy of intraarticular ADMSC administration for limb function improvement in dogs with severe OA.

          Results

          Eight lame dogs with severe hip OA and a control group of 5 sound dogs were used for this study. Results were statistically analyzed to detect a significant increase in peak vertical force (PVF) and vertical impulse (VI) in treated dogs. Mean values of PVF and VI were significantly improved after treatment of the OA groups, reaching 53.02% and 14.84% of body weight, respectively, at day 180, compared with only 43.56% and 12.16% at day 0.

          Conclusion

          This study objectively demonstrated that intraarticular ADMSC therapy resulted in reduced lameness due to OA.

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          Most cited references19

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          The potential impact of the preparation rich in growth factors (PRGF) in different medical fields.

          Mikel Sánchez, Isabel Andia, Gorka Orive … (2007)
          Platelet-rich preparations constitute a relatively new biotechnology for the stimulation and acceleration of tissue healing and bone regeneration. The versatility and biocompatibility of this approach has stimulated its therapeutic use in numerous medical and scientific fields including dentistry, oral implantology, orthopaedics, ulcer treatment, tissue engineering among others. Here we discuss the important progress that has been accomplished in the field of platelet-rich preparations in the last few years. Some of the most interesting therapeutic applications of this technology are discussed as are some of the limitations, future challenges and directions in the field.
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            Effect of adipose-derived mesenchymal stem and regenerative cells on lameness in dogs with chronic osteoarthritis of the coxofemoral joints: a randomized, double-blinded, multicenter, controlled trial.

            Justin Black, S Harman, D Aron … (2006)
            Autologous stem cell therapy in the field of regenerative veterinary medicine involves harvesting tissue, such as fat, from the patient, isolating the stem and regenerative cells, and administering the cells back to the patient. Autologous adipose-derived stem cell therapy has been commercially available since 2003, and the current study evaluated such therapy in dogs with chronic osteoarthritis of the hip. Dogs treated with adipose-derived stem cell therapy had significantly improved scores for lameness and the compiled scores for lameness, pain, and range of motion compared with control dogs. This is the first randomized, blinded, placebo-controlled clinical trial reporting on the effectiveness of stem cell therapy in dogs.
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              Mobilization of bone marrow-derived mesenchymal stem cells into the injured tissues after intraarticular injection and their contribution to tissue regeneration.

              Muhammad Agung, Mitsuo Ochi, Shinobu Yanada … (2006)
              The purpose of present study was to evaluate active mobilization effect of mesenchymal stem cells (MSCs) into injured tissues after intraarticular injection of MSCs, and to evaluate their contribution to tissue regeneration. MSCs, which were obtained from green fluorescent protein (GFP) transgenic Sprague-Dawley (SD) rat and cultivated, were injected into normal SD rats in which multiple tissues had been injured including anterior cruciate ligament (ACL), medial meniscus, and articular cartilage of the femoral condyles. At 4 weeks after injection of MSCs, fluorescent microscopic observation, immunohistochemical or histological examinations were performed to evaluate mobilization of MSCs into injured tissue and their contribution to tissue regeneration. In the group of 1 x 10(6) MSCs injection, GFP positive cells could mobilize into the injured ACL alone in all 8 knees. In the group of 1 x 10(7) MSCs injection, GFP positive cells were observed in the injured site of ACL in all 8 knees and in the injured site of medial meniscus and cartilage of femoral condyles in 6 of 8 knees. More interestingly, extracellular matrix stained by toluidine blue was present around GFP positive cells in the injured femoral condyles cartilage and medial meniscus, indicating tissue regeneration. Intraarticularly injected MSCs could mobilize into the injured tissues, and probably contributed to tissue regeneration. This study demonstrated the possibility of intraarticular injection of MSCs for the treatment of intraarticular tissue injuries including ACL, meniscus, or cartilage. If this treatment option is established, it can be minimally invasive compared to conventional surgeries for these tissues.
              Article 0 comments Cited 70 times – based on 0 reviews     Review now
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                Author and article information

                Contributors
                Jose M Vilar
                Manuel Morales
                Angelo Santana
                Giuseppe Spinella
                Mónica Rubio
                Belen Cuervo
                Ramón Cugat
                Jose M Carrillo
                Journal
                Journal ID (nlm-ta): BMC Vet Res
                Journal ID (iso-abbrev): BMC Vet. Res
                Title: BMC Veterinary Research
                Publisher: BioMed Central
                ISSN (Electronic): 1746-6148
                Publication date Collection: 2013
                Publication date (Electronic): 2 July 2013
                Volume: 9
                Page: 131
                Affiliations
                [1 ]Department of Animal Pathology, Faculty of Veterinary Medicine, Universidad de Las Palmas de Gran Canaria, Trasmontaña S/N, Arucas 35413 Las Palmas, Spain
                [2 ]Department of Veterinary Science, University Alma Mater of Bologna, via Tolara di Sopra 50, Ozzano dell’Emilia (BO), Italy
                [3 ]Departamento de Medicina y Cirugía Animal, Universidad CEU Cardenal Herrera, C/ Tirant lo Blanc, 7, 46117 Alfara del Patriarca Valencia, Spain
                [4 ]Fundación García Cugat, Madrazo 43, 08006 Barcelona, Spain
                [5 ]Instituto de Ciencias Biomédicas Universidad CEU Cardenal Herrera, C/del pozo s/n, 46115 Alfara del Patriarca Valencia, Spain
                [6 ]Artroscopia GC. Hospital Quirón Barcelona, Plaza Alfonso Comí, 12, Barcelona, Spain
                Article
                Publisher ID: 1746-6148-9-131
                DOI: 10.1186/1746-6148-9-131
                PMC ID: 3716942
                PubMed ID: 23819757
                SO-VID: 5fdac1c9-9497-40a7-9dcb-8adb27133b7d
                Copyright © Copyright © 2013 Vilar et al.; licensee BioMed Central Ltd.
                License:

                This is an Open Access article distributed under the terms of the Creative Commons Attribution License ( http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

                History
                Date received : 22 January 2013
                Date accepted : 24 June 2013
                Categories
                Subject: Research Article

                ScienceOpen disciplines: Veterinary medicine
                Keywords: osteoarthrosis,hip,adipose-derived mesenchymal stem cells,force platform,prgf
                Data availability:
                ScienceOpen disciplines: Veterinary medicine
                Keywords: osteoarthrosis, hip, adipose-derived mesenchymal stem cells, force platform, prgf

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