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      Diurnal Variations in Intraocular Pressure in the Albino Rabbit: Relationship to Morning Intraocular Pressure

      a,b , b

      Ophthalmic Research

      S. Karger AG

      Albino rabbits, Intraocular pressure, Diurnal variations

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          Abstract

          Intraocular pressure (IOP) measurements were carried out in 88 adult male New Zealand white rabbits. IOP of each rabbit was measured in the morning (8.00–9.00 h), at noon (12.00–13.00 h) and in the afternoon (16.00–17.00 h) on 6 separate days. A linear relationship was found between the noon IOP and the morning IOP: noon IOP = 0.77 morning IOP + 4.37; r = 0.950. This regression line intersects the line of IOP equality (morning IOP = noon IOP) at morning IOP = 19 mm Hg. Thus, in animals with morning IOP < 19 mm Hg, there was an increase in IOP between the morning and noon readings whereas animals with a higher morning IOP (20–30 mm Hg) showed a progressive decrease in the morning-noon IOP. This observed relationship explains the disparity among previously published IOP diurnal curves for rabbits. It is suggested that future studies of IOP changes should present IOP values and not only relative changes in IOP (ΔIOP or percent change in IOP).

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          Author and article information

          Journal
          ORE
          Ophthalmic Res
          10.1159/issn.0030-3747
          Ophthalmic Research
          S. Karger AG
          0030-3747
          1423-0259
          1997
          1997
          11 December 2009
          : 29
          : 2
          : 110-116
          Affiliations
          aDepartment of Pharmacology and Therapeutics, University of Florida College of Medicine, Gainesville, Fla., USA; bPharmos Corp., Rehovot, Israel
          Article
          268004 Ophthalmic Res 1997;29:110–116
          10.1159/000268004
          9154537
          © 1997 S. Karger AG, Basel

          Copyright: All rights reserved. No part of this publication may be translated into other languages, reproduced or utilized in any form or by any means, electronic or mechanical, including photocopying, recording, microcopying, or by any information storage and retrieval system, without permission in writing from the publisher. Drug Dosage: The authors and the publisher have exerted every effort to ensure that drug selection and dosage set forth in this text are in accord with current recommendations and practice at the time of publication. However, in view of ongoing research, changes in government regulations, and the constant flow of information relating to drug therapy and drug reactions, the reader is urged to check the package insert for each drug for any changes in indications and dosage and for added warnings and precautions. This is particularly important when the recommended agent is a new and/or infrequently employed drug. Disclaimer: The statements, opinions and data contained in this publication are solely those of the individual authors and contributors and not of the publishers and the editor(s). The appearance of advertisements or/and product references in the publication is not a warranty, endorsement, or approval of the products or services advertised or of their effectiveness, quality or safety. The publisher and the editor(s) disclaim responsibility for any injury to persons or property resulting from any ideas, methods, instructions or products referred to in the content or advertisements.

          Page count
          Pages: 7
          Categories
          Original Paper

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