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      Osteosarcoma in Sprague-Dawley rats after long-term treatment with teriparatide (human parathyroid hormone (1-34)).

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          Abstract

          Teriparatide, a therapeutic agent for osteoporosis, has been reported to increase the incidences of bone neoplasms such as osteosarcoma when administered subcutaneously to Fischer 344 (F344) rats for a long term, but its non-carcinogenic dose level following 2-year daily administration has not been established. Here we report detailed studies on the carcinogenicity of teriparatide following long-term administration. When teriparatide was administered subcutaneously to male and female Sprague-Dawley (SD) rats daily for 2 years, the incidence of osteosarcoma was increased at 13.6 µg/kg/day. The non-carcinogenic dose level was 4.5 µg/kg/day for both males and females. The development of osteosarcoma in SD rats depends on the dose level of, and treatment duration with, teriparatide. Responses of the bones to teriparatide were similar between F344 and SD rats in many aspects. These results suggested that the carcinogenic potential of teriparatide in SD rats is essentially the same as in F344 rats.

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          Author and article information

          Journal
          J Toxicol Sci
          The Journal of toxicological sciences
          1880-3989
          0388-1350
          2012
          : 37
          : 3
          Affiliations
          [1 ] Pharmaceuticals Research Center, Asahi Kasei Pharma Corporation, Shizuoka, Japan. watanabe.ab@om.asahi-kasei.com.jp
          Article
          DN/JST.JSTAGE/jts/37.617
          10.2131/jts.37.617
          22688001
          5fe16bf5-7962-41aa-9838-409e0038464c
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