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      Developing Carrier Complexes for “Caged NO”: RuCl 3(NO)(H 2O) 2 Complexes of Dipyridylamine, (dpaH), N,N,N'N'-Tetrakis (2-Pyridyl) Adipamide, (tpada), and (2-Pyridylmethyl) Iminodiacetate, (pida 2-)

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          Abstract

          Delivery agents which can carry the {Ru(NO)} 6 chromophore (“caged NO”) are desired for vasodilation and for photodynamic therapy of tumors. Toward these goals, complexes derived from [RuCl 3(NO)(H 2O) 2]= ( 1) have been prepared using dipyridylamine (dpaH) as mono and bis adducts, [Ru(NO)Cl 3(dpaH)] = ( 2) and [Ru(NO)Cl(dpaH) 2]Cl 2 = ( 3). The dpaH ligands coordinate cis to the Ru(NO) axis.The mono derivative is a model for a potential DNA groove-spanning binuclear complex {[RuNO)Cl 3] 2(tpada)} = ( 4) which has two DNA-coordinating Ru II centers, photo-labile {Ru(NO)} 6 sites, and a groove-spanning tether moiety.The binuclear assembly is prepared from the tethered dipyridylamine ligand N,N,N',N'-tetrakis(2-pyridylmethyl)adipamide (tpada) which has recently been shown to provide a binuclear carrier complex suited to transporting Ru II and Pd II agents. A related complex, [Ru(NO)Cl(pida)] = ( 5) with the {Ru(NO)} 6 moiety bound to (2-pyridylmethyl) iminodiacetate (pida 2-) is also characterized as a potential “caged NO” carrier. Structural information concerning the placement of the pyridyl donor groups relative to the {Ru(NO)} 6 unit has been obtained from 1H and 13C NMR and infrared methods, noting that a pyridyl donor trans to NO+ causes “trans strengthening” of this ligand for [Ru(NO)Cl(pida)], whereas placement of pyridyl groups cis to NO+ causes a weakening of the N-O bond and a lower NO stretching frequency in the dpa-based complexes.

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          Author and article information

          Journal
          Met Based Drugs
          Metal-Based Drugs
          Hindawi Publishing Corporation
          0793-0291
          2000
          : 7
          : 2
          : 67-75
          Affiliations
          [ ] Department of Chemistry University of Pittsburgh Pittsburgh Pennsylvania 15260 USA
          Article
          S0793029100000124
          10.1155/MBD.2000.67
          2365204
          18475928
          Copyright © 2000 Hindawi Publishing Corporation.

          This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

          Categories
          Research Article

          Pharmacology & Pharmaceutical medicine

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