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      Tandem catalysis: a taxonomy and illustrative review

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      Coordination Chemistry Reviews
      Elsevier BV

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          Lanthanide complexes in multifunctional asymmetric catalysis.

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            Swinging arms and swinging domains in multifunctional enzymes: catalytic machines for multistep reactions.

            R Perham (1999)
            Multistep chemical reactions are increasingly seen as important in a growing number of complex biotransformations. Covalently attached prosthetic groups or swinging arms, and their associated protein domains, are essential to the mechanisms of active-site coupling and substrate channeling in a number of the multifunctional enzyme systems responsible. The protein domains, for which the posttranslational machinery in the cell is highly specific, are crucially important, contributing to the processes of molecular recognition that define and protect the substrates and the catalytic intermediates. The domains have novel folds and move by virtue of conformationally flexible linker regions that tether them to other components of their respective multienzyme complexes. Structural and mechanistic imperatives are becoming apparent as the assembly pathways and the coupling of multistep reactions catalyzed by these dauntingly complex molecular machines are unraveled.
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              Sequencing Reactions with Samarium(II) Iodide.

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                Author and article information

                Journal
                Coordination Chemistry Reviews
                Coordination Chemistry Reviews
                Elsevier BV
                00108545
                December 2004
                December 2004
                : 248
                : 21-24
                : 2365-2379
                Article
                10.1016/j.ccr.2004.05.012
                602a4006-62ed-445f-b4ca-756803ad5b2b
                © 2004

                http://www.elsevier.com/tdm/userlicense/1.0/

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