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      Glomerulotubular Balance in Hypertensive Rats

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          Abstract

          The relationship between glomerulotubular balance and the development of hypertension was studied in subtotally nephrectomized rats, with or without previous chronic salt loading, 1–4 weeks after the operation. The creatinine clearance (Co) was similarly reduced in all the groups as compared to control rats. The maximal glucose reabsorption (Tm<sub>G1C</sub>) was also decreased in all experimental groups with the sole exception of saline-loaded hypertensive rats in which the fall did not reach the significance level. The ratio Tm<sub>G1C</sub>/C<sub>cr</sub>, which was taken as an index of glomerulotubular balance, was high in the hypertensive groups and further enhanced by saline loading. Peak values of Tm<sub>G1C</sub>/C<sub>cr</sub> were detected in the 1st week after operation and declined thereafter reaching normal levels in the hypertensive rats but not in the hypertensive saline-loaded animals. Results suggest that an early glomerulotubular imbalance is in some way related to the development of hypertension in subtotally nephrectomized rats. This abnormality is apparently corrected by the counterbalancing effect of increased renal perfusion pressure but can be unmasked by saline loading.

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          Author and article information

          Journal
          NEF
          Nephron
          10.1159/issn.1660-8151
          Nephron
          S. Karger AG
          1660-8151
          2235-3186
          1981
          1981
          02 December 2008
          : 27
          : 2
          : 89-93
          Affiliations
          Fisiología Humana, Departamento de Ciencias Biológicas, Facultad de Farmacia y Bioquímica, UBA, and Instituto de Investigaciones Cardiológicas, Buenos Aires, Argentina
          Article
          182031 Nephron 1981;27:89–93
          10.1159/000182031
          7266707
          © 1981 S. Karger AG, Basel

          Copyright: All rights reserved. No part of this publication may be translated into other languages, reproduced or utilized in any form or by any means, electronic or mechanical, including photocopying, recording, microcopying, or by any information storage and retrieval system, without permission in writing from the publisher. Drug Dosage: The authors and the publisher have exerted every effort to ensure that drug selection and dosage set forth in this text are in accord with current recommendations and practice at the time of publication. However, in view of ongoing research, changes in government regulations, and the constant flow of information relating to drug therapy and drug reactions, the reader is urged to check the package insert for each drug for any changes in indications and dosage and for added warnings and precautions. This is particularly important when the recommended agent is a new and/or infrequently employed drug. Disclaimer: The statements, opinions and data contained in this publication are solely those of the individual authors and contributors and not of the publishers and the editor(s). The appearance of advertisements or/and product references in the publication is not a warranty, endorsement, or approval of the products or services advertised or of their effectiveness, quality or safety. The publisher and the editor(s) disclaim responsibility for any injury to persons or property resulting from any ideas, methods, instructions or products referred to in the content or advertisements.

          Page count
          Pages: 5
          Categories
          Original Paper

          Cardiovascular Medicine, Nephrology

          Glomerulotubular balance, Arterial hypertension, Saline load

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