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      Effects of Oat Bran Addition on the Growth Performance and Intestinal Health of Nile Tilapia ( Oreochromis niloticus) Exposed to Copper Ions


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          This study investigated the effects of the oat bran addition on the growth performance and intestinal health of Nile tilapia ( Oreochromis niloticus) exposed to copper ions. Four groups of diets containing 0%, 5%, 10%, and 20% oat bran were fed to Nile tilapia for four weeks. The results showed that oat bran had a dose-dependent effect on the growth performance of Nile tilapia. The addition of oat bran can increase the relative abundance of Delftia, which is capable of degrading heavy metals in the intestinal tract and alleviating the intestinal damage caused by copper ion stress. Compared to the control group, the 5% oat bran group had an increased intestinal antioxidant capacity. The relative gene expression of proinflammatory factors (NF- κB, IL-1 β) was significantly downregulated in the 5% oat bran group ( P < 0.05), and the relative gene expression of anti-inflammatory factors (TGF- β), HIF-1 α, occludin, and claudin was significantly upregulated ( P < 0.05). In conclusion, we suggest that 5% oat bran should be added to the diet to improve the growth performance of Nile tilapia and alleviate the negative effects of copper ion stress on intestinal health.

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                Author and article information

                Aquac Nutr
                Aquac Nutr
                Aquaculture Nutrition
                20 June 2023
                : 2023
                : 5329546
                1College of Grassland Science and Technology, China Agricultural University, Beijing 100193, China
                2College of Life Science, North China University of Science and Technology, Tangshan 063210, China
                3Key Laboratory for Feed Biotechnology of the Ministry of Agriculture and Rural Affairs, Feed Research Institute, Chinese Academy of Agricultural Sciences, Beijing 100081, China
                Author notes

                Academic Editor: Yanjiao Zhang

                Author information
                Copyright © 2023 Chunze Guo et al.

                This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

                : 4 January 2023
                : 12 May 2023
                : 15 May 2023
                Funded by: National Basic Research Program of China (973 Program)
                Award ID: 2021YFD1300300
                Funded by: Earmarked Fund for Modern Agro-industry Technology Research System
                Award ID: CARS-07-E-3
                Research Article


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