30
views
0
recommends
+1 Recommend
0 collections
    0
    shares
      • Record: found
      • Abstract: found
      • Article: found
      Is Open Access

      Biodegradable Polymer Membranes Applied in Guided Bone/Tissue Regeneration: A Review

      review-article

      Read this article at

      Bookmark
          There is no author summary for this article yet. Authors can add summaries to their articles on ScienceOpen to make them more accessible to a non-specialist audience.

          Abstract

          Polymer membranes have been widely used in guided tissue regeneration (GTR) and guided bone regeneration (GBR). In this review, various commercially available membranes are described. Much attention is paid to the recent development of biodegradable polymers applied in GTR and GBR, and the important issues of biodegradable polymeric membranes, including their classification, latest experimental research and clinical applications, as well as their main challenges are addressed. Herein, natural polymers, synthetic polymers and their blends are all introduced. Pure polymer membranes are biodegradable and biocompatible, but they lack special properties such as antibacterial properties, osteoconductivity, and thus polymer membranes loaded with functional materials such as antibacterial agents and growth factors show many more advantages and have also been introduced in this review. Despite there still being complaints about polymer membranes, such as their low mechanical properties, uncontrollable degradation speed and some other drawbacks, these problems will undoubtedly be conquered and biodegradable polymers will have more applications in GTR and GBR.

          Related collections

          Most cited references128

          • Record: found
          • Abstract: not found
          • Article: not found

          Biodegradable polymers as biomaterials

            Bookmark
            • Record: found
            • Abstract: found
            • Article: not found

            Guided Bone Regeneration: biological principle and therapeutic applications.

            The Guided Bone Regeneration (GBR) treatment concept advocates that regeneration of osseous defects is predictably attainable via the application of occlusive membranes, which mechanically exclude non-osteogenic cell populations from the surrounding soft tissues, thereby allowing osteogenic cell populations originating from the parent bone to inhabit the osseous wound. The present review discusses the evolution of the GBR biological rationale and therapeutic concept over the last two decades. Further, an overview of the GBR research history is provided with specific focus on the evidence available on its effectiveness and predictability in promoting the regeneration of critical size cranio-maxillo-facial defects, the neo-osteogenesis potential and the reconstruction of atrophic alveolar ridges before, or in conjunction with, the placement of dental implants. The authors conclude that future research should focus on (a) the investigation of the molecular mechanisms underlying the wound healing process following GBR application; (b) the identification of site and patient related factors which impact on the effectiveness and predictability of GBR therapy and (c) the evaluation of the pathophysiology of the GBR healing process in the presence of systemic conditions potentially affecting the skeletal system.
              Bookmark
              • Record: found
              • Abstract: found
              • Article: not found

              Bioactive glasses beyond bone and teeth: emerging applications in contact with soft tissues.

              The applications of bioactive glasses (BGs) have to a great extent been related to the replacement, regeneration and repair of hard tissues, such as bone and teeth, and there is an extensive bibliography documenting the role of BGs as bone replacement materials and in bone tissue engineering applications. Interestingly, many of the biochemical reactions arising from the contact of BGs with bodily fluids, in particular the local increase in concentration of various ions at the glass-tissue interface, are also relevant to mechanisms involved in soft tissue regeneration. An increasing number of studies report on the application of BGs in contact with soft tissues, aiming at exploiting the well-known bioactive properties of BGs in soft tissue regeneration and wound healing. This review focuses on research, sometimes involving preliminary in vitro studies but also in vivo evidence, that demonstrates the suitability of BGs in contact with tissues outside the skeletal system, which includes studies investigating vascularization, wound healing and cardiac, lung, nerve, gastrointestinal, urinary tract and laryngeal tissue repair using BGs in various forms of particulates, fibers and nanoparticles with and without polymer components. Potentially active mechanisms of interaction of BGs and soft tissues based on the surface bioreactivity of BGs and on biomechanical stimuli affecting the soft tissue-BG collagenous bonding are discussed based on results in the literature.
                Bookmark

                Author and article information

                Contributors
                Role: Academic Editor
                Journal
                Polymers (Basel)
                Polymers (Basel)
                polymers
                Polymers
                MDPI
                2073-4360
                29 March 2016
                April 2016
                : 8
                : 4
                : 115
                Affiliations
                [1 ]Department of Prosthodontics, Affiliated Stomatological Hospital of Nanchang University, Nanchang 330006, China; 406531513386@ 123456email.ncu.edu.cn (J.W.); 406531514649@ 123456email.ncu.edu.cn (Z.Z.)
                [2 ]College of Chemistry, Nanchang University, Nanchang 330031, China; 5901213058@ 123456email.ncu.edu.cn (H.L.); 5503113042@ 123456email.ncu.edu.cn (P.X.)
                [3 ]College of Science, Nanchang Institute of Technology, Nanchang 330029, China; linawang@ 123456nit.edu.cn
                Author notes
                [* ]Correspondence: liaolan5106@ 123456ncu.edu.cn (L.L.); weijunchao@ 123456ncu.edu.cn (J.W.); Tel.: +86-0791-8635-0706 (L.L.); +86-0791-8396-8830 (J.W.)
                Article
                polymers-08-00115
                10.3390/polym8040115
                6431950
                30979206
                60522d55-4af6-464c-8233-74d7cd684f8f
                © 2016 by the authors.

                Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons by Attribution (CC-BY) license ( http://creativecommons.org/licenses/by/4.0/).

                History
                : 27 February 2016
                : 24 March 2016
                Categories
                Review

                biodegradable polymer,gtr,gbr,membrane,collagen,polylactide
                biodegradable polymer, gtr, gbr, membrane, collagen, polylactide

                Comments

                Comment on this article