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      Comparative metagenomics of microbial communities.

      Science (New York, N.Y.)

      Animals, Archaea, classification, genetics, metabolism, Bacteria, Bacterial Proteins, Biodiversity, Biofilms, Bone and Bones, microbiology, Computational Biology, Ecosystem, Energy Metabolism, Eukaryotic Cells, Gene Library, Genes, Genes, Bacterial, Genome, Genome, Bacterial, Genomics, Molecular Sequence Data, Operon, Phylogeny, Polymerase Chain Reaction, Proteins, Proteome, Seawater, Sequence Analysis, DNA, Soil Microbiology, Whales

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          Abstract

          The species complexity of microbial communities and challenges in culturing representative isolates make it difficult to obtain assembled genomes. Here we characterize and compare the metabolic capabilities of terrestrial and marine microbial communities using largely unassembled sequence data obtained by shotgun sequencing DNA isolated from the various environments. Quantitative gene content analysis reveals habitat-specific fingerprints that reflect known characteristics of the sampled environments. The identification of environment-specific genes through a gene-centric comparative analysis presents new opportunities for interpreting and diagnosing environments.

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          Journal
          15845853
          10.1126/science.1107851

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