On the parametrization of lateral dose profiles in proton radiation therapy.

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Abstract

The accurate evaluation of the lateral dose profile is an important issue in the field of proton radiation therapy. The beam spread, due to Multiple Coulomb Scattering (MCS), is described by the Molière's theory. To take into account also the contribution of nuclear interactions, modern Treatment Planning Systems (TPSs) generally approximate the dose profiles by a sum of Gaussian functions. In this paper we have compared different parametrizations for the lateral dose profile of protons in water for therapeutical energies: the goal is to improve the performances of the actual treatment planning.

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Journal

Journal ID (iso-abbrev): Phys Med

Title: Physica medica : PM : an international journal devoted to the applications of physics to medicine and biology : official journal of the Italian Association of Biomedical Physics (AIFB)

Publisher: Elsevier BV

ISSN (Electronic): 1724-191X

ISSN (Print): 1120-1797

Publication date (Electronic): Jul 2015

Volume: 31

Issue: 5

Affiliations

[1 ] Istituto Nazionale di Fisica Nucleare, Sezione di Pavia, Pavia, Italy; Dipartimento di Fisica, Università di Pavia, Pavia, Italy; Department of Medical Physics, Ludwig Maximilians University, Munich, Germany.

[2 ] Medical Physics Unit, Centro Nazionale di Adroterapia Oncologica, Pavia, Italy.

[3 ] Istituto Nazionale di Fisica Nucleare, Sezione di Pavia, Pavia, Italy; Dipartimento di Fisica, Università di Pavia, Pavia, Italy.

[4 ] Istituto Nazionale di Fisica Nucleare, Sezione di Pavia, Pavia, Italy. Electronic address: andrea.fontana@pv.infn.it.

[5 ] Dipartimento di Fisica, Università di Pavia, Pavia, Italy.

[6 ] Department of Medical Physics, Ludwig Maximilians University, Munich, Germany; Heidelberg Ion Beam Therapy Center, University Hospital Heidelberg, Heidelberg, Germany.

Article

Publisher Item ID: S1120-1797(15)00114-3

DOI: 10.1016/j.ejmp.2015.05.004

PubMed ID: 26032003

SO-VID: 606fda4b-5230-45a8-9a86-36f60167f77e

History

Keywords: Lateral dose distribution,Proton therapy,TPS optimization

Data availability:

Keywords: Lateral dose distribution, Proton therapy, TPS optimization

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