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      Cortical inhibition, excitation, and connectivity in schizophrenia: a review of insights from transcranial magnetic stimulation.

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          Abstract

          Schizophrenia (SCZ) is a debilitating mental illness with an elusive pathophysiology. Over the last decade, theories emphasizing cortical dysfunction have received increasing attention to explain the heterogeneous symptoms experienced in SCZ. Transcranial magnetic stimulation (TMS) is a noninvasive form of brain stimulation that is particularly suited to probing the fidelity of specific excitatory and inhibitory neuronal populations in conscious humans. In this study, we review the contribution of TMS in assessing inhibitory and excitatory neuronal populations and their long-range connections in SCZ. In addition, we discuss insights from combined TMS and electroencephalography into the functional consequences of impaired excitation/inhibition on cortical oscillations in SCZ.

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          Author and article information

          Journal
          Schizophr Bull
          Schizophrenia bulletin
          1745-1701
          0586-7614
          May 2014
          : 40
          : 3
          Affiliations
          [1 ] *To whom correspondence should be addressed; Monash Alfred Psychiatry Research Centre, Central Clinical School, The Alfred and Monash University, Level 4, 607 Street, Kilda Road, Melbourne, Victoria 3004, Australia; tel: +61-3-9076-6593, fax: +61-3-9076-6588, e-mail: nigel.rogasch@monash.edu.
          Article
          sbt078
          10.1093/schbul/sbt078
          23722199
          607a5630-4b34-4a38-ac23-0f1272b3f901
          History

          GABA,NMDA,connectivity,cortical inhibition
          GABA, NMDA, connectivity, cortical inhibition

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