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      A design of fluorescent probes for superoxide based on a nonredox mechanism.

      Journal of the American Chemical Society

      Benzenesulfonates, chemistry, Cytochrome P-450 Enzyme System, Drug Design, Fluoresceins, chemical synthesis, Fluorescent Dyes, Fluorometry, Glutathione, Hydrogen Peroxide, Hypoxanthine, NADP, Oxidation-Reduction, Sulfonic Acids, Superoxide Dismutase, Superoxides, analysis, Xanthine Oxidase

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          Abstract

          Fluorometric detection of O2-* is performed based on desulfonylation of 3 to the corresponding fluoresceins 4 through nucleophilic substitution, and this fluorescing process is quite specific toward O2-* over H2O2, t-BuOOH, NaOCl, 1O2, HO*, NO*, and ONOO-. Furthermore, effects of glutathione, cytochrome P450 reductase/NADPH, and diaphorase/NADH are relatively small on the fluorescing process of probe 3 with X = Y = F, which is useful to detect O2-* released from neutrophils stimulated by phorbol myristate acetate with satisfactory sensitivity.

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          Journal
          15631452
          10.1021/ja047018k

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