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      Co-Existence of Multicentric Castleman's Disease and Kaposi's Sarcoma

      case-report

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          Abstract

          Castleman's disease (CD) or giant lymph node hyperplasia is a rare disorder that can be unicentric or multicentric. Multicentric Castleman's disease (MCD) is manifested by generalized lymphadenopathy, hepatosplenomegaly, polyclonal hypergammaglobulinemia, hematological abnormality, and constitutional symptoms. Human herpesvirus 8 (HHV-8) infection is present in nearly 100% MCD associated with HIV-1 infection, but in about 50% of cases of HIV negative. Herein, we report a 77-year-old man with systemic involvement and skin lesions on the anterior aspect of both legs in the previous site of saphenous vein angioplasty. Co-existence of MCD with Kaposi's sarcoma (KS) led us to present this rare case.

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          Castleman's disease and lymphoma: report of eight cases in HIV-negative patients and literature review.

          Eric Oksenhendler, Jean Soulier, Jean Piette … (2002)
          Castleman's disease (CD) is a rare atypical lymphoproliferative disorder associated with a risk of developing malignant lymphoma. We have recorded 8 HIV-negative patients presenting this association, 6 with non-Hodgkin's lymphoma (NHL) and 2 with Hodgkin's disease (HD). After literature review, we analyzed all reported cases of association CD-NHL (n = 23) and CD-HD (n = 27). NHL is more often associated with multicentric CD, its diagnosis being concurrent with CD diagnosis or occurring within 2 years. B-NHL is predominant (71%), and mantle cell lymphoma represents 40% of these B-NHL cases. NHL displays an aggressive course and is liable for death, especially in multicentric CD. HD occurs in localized CD of plasma cell type, usually in the same areas, is more often of interfollicular subtype, and its clinical course seems better than NHL. The association of CD and lymphoma seems to be more than coincidental, and its pathogenesis is discussed. Copyright 2002 Wiley-Liss, Inc.
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            Castleman's disease - hyaline vascular type - clinical, cytological and histological features with review of literature.

            Arnab Ghosh, Seema Pradhan, O Talwar (2016)
            Castleman's disease (CD) is a rare disease of lymph node with two identified forms - the hyaline vascular (HV) type or angiofollicular type and plasma cell (PC) type. It usually presents as localized or systemic lymphadenopathy or even as extra nodal mass and may give rise to several differential diagnoses. Fine needle aspiration cytology (FNAC), as the initial investigation, may be misleading. Excision biopsy usually gives the diagnosis. This study analyzes the clinical, cytological and histological features of CD of HV type. All the cases of CD reported between 2001 and March 2008 have been reviewed. Cytology and histopathology slides of all cases were reviewed by two reporting pathologists independently and the clinical records were analyzed. We had five cases of CD all of which presented as cervical lymphadenopathy of 1 to 5 cms in young patients. Patients were mostly asymptomatic with all relevant investigations within normal limits. The cytology findings mostly showed a predominance of small lymphocytes with capillary fragments. On excision biopsy, all cases were diagnosed as CD of HV type. CD should be kept as a differential of lymphadenopathy, especially in asymptomatic and young patients.
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              Diffuse hyperpigmented plaques as cutaneous manifestation of multicentric Castleman disease and treatment with thalidomide: Report of three cases

              Xiaoqing Zhao, Ruofei Shi, Xiaolong Jin … (2011)
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                Author and article information

                Journal
                Journal ID (nlm-ta): Indian J Dermatol
                Journal ID (iso-abbrev): Indian J Dermatol
                Journal ID (publisher-id): IJD
                Title: Indian Journal of Dermatology
                Publisher: Medknow Publications & Media Pvt Ltd (India )
                ISSN (Print): 0019-5154
                ISSN (Electronic): 1998-3611
                Publication date (Print): May-Jun 2015
                Volume: 60
                Issue: 3
                Page: 323
                Affiliations
                [1] From the Department of Dermatology, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran
                Author notes
                Address for correspondence: Dr. Nader Pazyar, Department of Dermatology, Imam Hospital, Azadegan Street, Ahvaz, Iran. E-mail: dr.pazyar@ 123456gmail.com
                Article
                Publisher ID: IJD-60-323b
                DOI: 10.4103/0019-5154.156457
                PMC ID: 4458972
                SO-VID: 608a2256-cd07-4754-98aa-5aa02fccdef4
                Copyright © Copyright: © Indian Journal of Dermatology
                License:

                This is an open-access article distributed under the terms of the Creative Commons Attribution-Noncommercial-Share Alike 3.0 Unported, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

                History
                Date received : May 2014
                Date accepted : August 2014
                Categories
                Subject: E-IJD Case Report

                ScienceOpen disciplines: Dermatology
                Keywords: giant lymph node hyperplasia,herpes virus 8,human immunodeficiency virus,human,kaposi,multi-centric castleman's disease,sarcoma
                Data availability:
                ScienceOpen disciplines: Dermatology
                Keywords: giant lymph node hyperplasia, herpes virus 8, human immunodeficiency virus, human, kaposi, multi-centric castleman's disease, sarcoma

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