Nadroparin-Induced Calcinosis cutis in Renal Transplant Recipients

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Abstract

Low-molecular-weight heparins are routinely used to prevent deep venous thrombosis following renal transplantation in our department. We report 2 patients who developed tender erythematous subcutaneous nodules with induration, ulceration and necrosis at the site of subcutaneous administration of nadroparin. Both patients were renal transplant recipients with impaired graft function and high serum calcium-phosphate products. The diagnosis calcinosis cutis was confirmed by technetium-99m bone scan and by histological examination of biopsies. Both patients showed spontaneous recovery several weeks after discontinuation of nadroparin. Patients with chronic renal failure and hyperphosphatemia may be predisposed to develop calcinosis cutis. In addition, the role of the calcium content of nadroparin is discussed.

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Journal ID (publisher-id): NEF

Journal ID (nlm-ta): Nephron

Journal ID (doi): 10.1159/issn.1660-8151

Title: Nephron

Publisher: S. Karger AG

ISSN (Print): 1660-8151

ISSN (Electronic): 2235-3186

Publication date Subscription-year: 2001

Publication date (Print): 2001

Publication date (Electronic): 16 March 2001

Volume: 87

Issue: 3

Pages: 279-282

Affiliations

Departments of ^aInternal Medicine, ^bPathology and ^cNephrology, University Hospital Nijmegen St. Radboud, Nijmegen, The Netherlands

Article

Publisher ID: 45927 Other ID: Nephron 2001;87:279–282

DOI: 10.1159/000045927

PubMed ID: 11287765

SO-VID: 60a3473d-80a4-45b8-85af-7e85b1121b3f

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Nadroparin-Induced Calcinosis cutis in Renal Transplant Recipients

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Karger: Nephrology

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